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| 哌嗪类抗肿瘤药物研究:双哌嗪双季铵盐类化合物的合成 | |
| 引用本文： | 李润涛,陈恒昌,杨锦宗. 哌嗪类抗肿瘤药物研究:双哌嗪双季铵盐类化合物的合成[J]. 药学学报, 1995, 30(1): 63-69 |
| 作者姓名： | 李润涛 陈恒昌 杨锦宗 |
| 作者单位： | 郑州大学化学系，大连理工大学精细化工系 |
| 摘 要： | 哌嗪类抗肿瘤药物研究：双哌嗪双季铵盐类化合物的合成李润涛，陈恒昌，杨锦宗（郑州大学化学系４５００５２；大连理工大学精细化工系１１６０１２）Ｐｉｐｏｂｒｏｍａｎ（Ⅰ）（１）和ｓｐｉｒｏｂｒｏｍｉｎｅ（Ⅱ）（２）是两种哌嗪类抗肿瘤药物，尽管它们都有较好的... |
| 关 键 词： | 双哌嗪双季铵盐 抗肿瘤药物 |
| 收稿时间： | 1994-03-21 |
STUDIES ON ANTITUMOR DRUG5 OF PIPERAZINES:SYNTHESIS OF DIPIPERAZINE DIQUATERNARY AMMONIUM DERlVATIVES |
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| RT Li,HC Chen and JZ Yang. STUDIES ON ANTITUMOR DRUG5 OF PIPERAZINES:SYNTHESIS OF DIPIPERAZINE DIQUATERNARY AMMONIUM DERlVATIVES[J]. Acta pharmaceutica Sinica, 1995, 30(1): 63-69 | |
| Authors: | RT Li HC Chen JZ Yang |
| Abstract: | Ten compounds of dipiperazine diquaternary ammoniums were synthesized from1-benzoylpiperazine by N-alkylation , quaternization and debenzoylation. The results of toxicitv andantitumor activity tests showed that, the greater the n and R in V, the higher the toxicity;Vc(n=6,R=CH3)and Ve(n=6,R=C2H5),which had middle fat solubility,possessed different activitiesagainst carcinoma S37 and quaternary ammonium plays a certain part in adjustment of oil-waterparrtition coefficient. |
| Keywords: | Dipiperazine diquaternary ammonium Antitumor drugs |
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