| γ-去氢骆驼蓬碱等咔啉类生物碱的辐射防护作用 |
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| 引用本文： | 利国威,桑培根,潘国英. γ-去氢骆驼蓬碱等咔啉类生物碱的辐射防护作用[J]. 药学学报, 1995, 30(9): 715-717 |
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| 作者姓名： | 利国威 桑培根 潘国英 |
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| 作者单位： | 中山医科大学肿瘤防治中心,广州 510060 |
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| 摘 要： | γ- Harmine(Ⅰ),’harmine(Ⅱ )and harmaline(Ⅲ )were isolated from PeganumHarmala L.( Zygophylaceae).Tests were conducted with mice to detect whether γ- harmine( a newcompound), harmine,harmof(Ⅳ)and harmalol(Ⅴ) are effective radioprotective compounds againstγ-ray irradiation, Intraperitoneal injection of the hydrochlorides of the four alkaloids 50～80mg·kg-1×1 in NIH male mice 30～45 minutes before 8.6～9. 7 Gy whole body 60Co irradiationsignificantly increased the survival effects(1. 33～2. 61)and 30-day survivai rate in comparison withcontrol mice.The results indicatethat γ- harmine exhibited relatively good radioprotective effect.γ-harmine is the first alkaloid isolated from a plant having ptotective effects against whole-body lethal irradiation in mice.
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| 关 键 词： | 辐射防护剂 驼骆蓬 γ-氢骆驼蓬碱 去氢骆驼蓬碱 咔啉类化合物 |
| 收稿时间： | 1994-06-24 |
KADIOPROTECTIVE EFFECT OF γ-HARMINE AND ITS CARBOLINE ANALOGUES |
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| GW Li,PG Liang and GY Pan. KADIOPROTECTIVE EFFECT OF γ-HARMINE AND ITS CARBOLINE ANALOGUES[J]. Acta pharmaceutica Sinica, 1995, 30(9): 715-717 |
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| Authors: | GW Li PG Liang GY Pan |
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| Abstract: | γ- Harmine(Ⅰ),’harmine(Ⅱ )and harmaline(Ⅲ )were isolated from PeganumHarmala L.( Zygophylaceae).Tests were conducted with mice to detect whether γ- harmine( a newcompound), harmine,harmof(Ⅳ)and harmalol(Ⅴ) are effective radioprotective compounds againstγ-ray irradiation, Intraperitoneal injection of the hydrochlorides of the four alkaloids 50～80mg·kg-1×1 in NIH male mice 30～45 minutes before 8.6～9. 7 Gy whole body 60Co irradiationsignificantly increased the survival effects(1. 33～2. 61)and 30-day survivai rate in comparison withcontrol mice.The results indicatethat γ- harmine exhibited relatively good radioprotective effect.γ-harmine is the first alkaloid isolated from a plant having ptotective effects against whole-body lethal irradiation in mice. |
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| Keywords: | peganum harmalaL. γ-Harmine Harmine Carbolines Radioprotective agents |
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