| 间硝地平对左室肥厚大鼠左室舒张功能及心脑线粒体和血管组织钙含量的影响 |
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| 引用本文： | 奚涛,饶曼人. 间硝地平对左室肥厚大鼠左室舒张功能及心脑线粒体和血管组织钙含量的影响[J]. 药学学报, 1995, 30(1): 6-6 |
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| 作者姓名： | 奚涛 饶曼人 |
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| 作者单位： | 南京医科大学心血管药理研究室，南京大学生化系 |
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| 摘 要： | 用肾性高血压左室肥厚(LVH)大鼠模型,观察了间硝地平(m-Nif)和硝苯地平(Nif)长期给药(ig20mg·kg-1·d-1持续9周)对左室舒张功能、左心室肌和大脑线粒体及血管钙含量的影响。与假手术组相比,LVH组左室顺应性明显下降,僵硬度增高,左心室肌和大脑线粒体及尾动脉和主动脉钙含量增加。与LVH组相比,m-Nif和Nif各组左室顺应性改善,僵硬度降低(P<0.01),左心室肌线粒体及尾动脉和主动脉钙含量较LVH组显著降低(P<0.01)。两药在作用强度上无显著差异。
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| 关 键 词： | 间硝地平 硝苯地平 肾性高血压 左室肥厚 左室舒张功能 钙 |
| 收稿时间： | 1994-03-23 |
EFFECTS OF m-NIFEDIPINE ON LEFT VENTRICULAR DIASTOLIC FUNCTLON AND Ca2+CONTENT OF MYOCARDIAL AND CEREBRAL MITOCHONDRIA AND ARTERY TISSUES IN LEFT VENTRICULAR HYPERTROPHIED RATS |
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| T Xi and MR Rao. EFFECTS OF m-NIFEDIPINE ON LEFT VENTRICULAR DIASTOLIC FUNCTLON AND Ca2+CONTENT OF MYOCARDIAL AND CEREBRAL MITOCHONDRIA AND ARTERY TISSUES IN LEFT VENTRICULAR HYPERTROPHIED RATS[J]. Acta pharmaceutica Sinica, 1995, 30(1): 6-6 |
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| Authors: | T Xi and MR Rao |
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| Abstract: | Left ventricular hypertrophy (LVH)was induced by renal hypertension in rats. m-Nifedipine(m-Nif, ig 20 mg·kg-1·d-1> for 9 wk)decreased LV weight in the renovascular hypertensive rats(P<0.01).The LV compliance in LVH group was significantly decreased compared with that in sham-operated group.The LV stiffness constant,Ca2+ content in left ventricular myocardial and cerebral mitochondrin, aorta,and tail artery were markedly raised.m-Nif could markedly reduce the LV stiffness constant,improve the LV compliance,and decrease the Ca2+content of left ventricular myocardial mitochondria and tissues of artery from LVH rats. These effects of m-Nif were similar to those of nifedipine at the same dosage. |
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| Keywords: | m-Nifedipine Nifedipine Renovascular hypertension Left ventricular hypertrophy Left ventricular diastolic function Calcium |
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