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| 人体液中喷布洛尔及其代谢物的GC/MS分析 | |
| 引用本文： | 申利,徐友宣,张长久,吴筠,王杉,崔凯荣. 人体液中喷布洛尔及其代谢物的GC/MS分析[J]. 药学学报, 1995, 30(9): 702-705 |
| 作者姓名： | 申利 徐友宣 张长久 吴筠 王杉 崔凯荣 |
| 作者单位： | 国家体委运动医学研究所兴奋剂检测中心 |
| 摘 要： | 用气相色谱一质谱联用(GC-MSD)系统分析方法检出了人尿中喷布洛尔的6个羟化代谢物,用Scp-Pak柱提取的方法检出了人血浆中的原型药物。并从分子结构上对此药物的代谢途径进行了研究。尿中提取和血中提取的回收率分别为90.83.%和85.88%,Gc-MSD的检测限为5pg。本方法适用于运动员兴奋剂的系统检查。 |
| 关 键 词： | 喷布洛尔 药物代谢 气相色谱-质谱联用 |
| 收稿时间： | 1994-12-30 |
ANALYSIS OF PENBUTOLOL AND ITS METABOLITES IN HUMAN BODY FLUID BYGAS CHROMATOGRAPHY-MASS SPECTROMETRY |
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| L Shen,YX Xu,CJ Zhang,Y Wu,S Wang and KR Cui. ANALYSIS OF PENBUTOLOL AND ITS METABOLITES IN HUMAN BODY FLUID BYGAS CHROMATOGRAPHY-MASS SPECTROMETRY[J]. Acta pharmaceutica Sinica, 1995, 30(9): 702-705 | |
| Authors: | L Shen YX Xu CJ Zhang Y Wu S Wang KR Cui |
| Abstract: | A method for the detection and identification of penbutolol and its metabolites inhuman body fluid by using gas chromatography-mass spectrometry was established. The urine wasextracted with diethyl ether-isopropanol and the plasma was extracted with Sep-Pas column. AfterTMS derivatization the sample was analyzed with GC-MSD.Six metabolites of Penbutolol wereFound in urine sample. The recovery was 90.83%for urine and 85.88%for plasma. The detectionlimit of penbutolol was 5pg. |
| Keywords: | Penbutolol Metabolite GC-MSD |
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