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| 粉防己碱对DOCA盐性高血压心肌肥厚大鼠心脏血流动力学的影响 | |
| 引用本文： | 徐毅,饶曼人. 粉防己碱对DOCA盐性高血压心肌肥厚大鼠心脏血流动力学的影响[J]. 药学学报, 1995, 30(2): 86-92 |
| 作者姓名： | 徐毅 饶曼人 |
| 作者单位： | 南京医科大学心血管药理研究室，湖南医科大学心血管生理研究室 |
| 摘 要： | 粉防己碱可显著降低DOCA盐性高血压心肌肥厚大鼠的血压,左室湿重;在工作心脏研究中发现其改善肥厚心室的收缩(AP,LVSP,+dp/dtmax)舒张(一dp/dtmax,LVEDP,T值)性能,尤以舒张性能改善明显,并恢复泵功能(CO)和冠脉流量(CF);在左室压力容积关系法研究显示有改善肥厚心室左室顺应性和左室僵硬度的作用。提示:Tet有逆转心肌肥厚和改善肥厚心肌舒张收缩功能,左室顺应性和心肌劲度的作用。 |
| 关 键 词： | 粉防己碱 左心室顺应性 左室肥厚 血流动力学 去氧皮质酮 |
| 收稿时间： | 1994-06-23 |
EFFECTS OF TETRANDRINE ON CARDIAC HEMODYNAMICS OF HYPERTROPHIED LEFT VENTRICLE FROM DEOXYCORTICOSTERONE-SALT HYPERTENSIVE RATS |
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| Y Xu and MR Rao. EFFECTS OF TETRANDRINE ON CARDIAC HEMODYNAMICS OF HYPERTROPHIED LEFT VENTRICLE FROM DEOXYCORTICOSTERONE-SALT HYPERTENSIVE RATS[J]. Acta pharmaceutica Sinica, 1995, 30(2): 86-92 | |
| Authors: | Y Xu and MR Rao |
| Abstract: | Effects of tetrandrine(Tet)on cardiac mass and hemodynamic parameters were studied in deoxycorticosterone-salt(DOCA-salt )hypertensive rats. Treatment with Tet(50mg·kg-1,qd X 9 wk)markedly lowered systolic blood pressure and left ventricular(LV) weight,Study on isolated working heart demonstrated that the Tet group compared with the LVH group, AP,LVSP,±dp/dtmax, LVDP,coronary blood flow and cardiac output were increased while LVEDP andT were decreased. Studies on LV pressure-volume relation showed that Tet can markedly improve theLV compliance and the LV stiffness constant of LVH ra. These findings suggest that the regression ofLVH in DOCA-salt hypertensive rats with Tet is associated with improvement of the contraction,relaxation and pump function , especially relaxation function and hemodynamics. |
| Keywords: | Left ventricular hypertrophy Hemodynamics Tetrandrine : Deoxycorticosterone Left ventricular compliance |
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