|
|||||
|
|
A highly polymorphic CA repeat marker at the human tumor necrosis factor alpha (TNFAα) locus |
|
| Authors: | Kazuhiro Tsukamoto Nobutaka Ohta Yasumasa Shirai M. Emi |
| Affiliation: | (1) Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan Tel. +81-44-733-5230; Fax +81-44-733-5192 e-mail: memi@nms.ac.jp., JP;(2) Department of Orthopedics, Nippon Medical School, Sendagi, Bunkyo-ku Tokyo 113-8603, Japan, JP |
| Abstract: | Tumor necrosis factor alpha (TNFα) in activated monocytes exerts cytotoxic activity and has a variety of other biological effects. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the gene located at 6p21.3. High heterozygosity (0.80) makes this polymorphism a useful marker in the genetic study of disorders affecting immunological response and cell differentiation. Received: June 2, 1998 / Accepted: June 24, 1998 |
| Keywords: | Tumor necrosis factor Dinucleotide repeat rheumatoid arthritis Obesity |
| 本文献已被 SpringerLink 等数据库收录！ | |