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| 自体白色血栓性猴局部脑缺血模型的建立 | |
| 引用本文： | 韦瑛,冯飞玲,黄志宏,邓燕贤,庾俊雄,邱维佳,何卓凯,周智鹏,甘瑞静,韦日明,容明智.自体白色血栓性猴局部脑缺血模型的建立[J].中国现代医学杂志,2005,15(24):3715-3717,3720. |
| 作者姓名： | 韦瑛 冯飞玲 黄志宏 邓燕贤 庾俊雄 邱维佳 何卓凯 周智鹏 甘瑞静 韦日明 容明智 |
| 作者单位： | 1. 桂林医学院,病理生理学教研室,广西,桂林,541004 2. 美国哈佛大学医学院麻省总医院,美国,02129 3. 桂林医学院,介入室,广西,桂林,541004 4. 桂林医学院,麻醉科,广西,桂林,541004 5. 桂林医学院,CT室,广西,桂林,541004 6. 桂林医学院,生物技术学院,广西,桂林,541004 |
| 基金项目： | 桂林医学院自选资助项目（YZ200302） |
| 摘 要： | 目的探讨自体白色血栓在局部脑缺血动物模型制作中的作用与意义。方法自体白色血栓经血管介入造影法准确导入至猴大脑中动脉（middle cerebral artery，MCA）M1分支。结果栓塞后：数字影像血管造影系统（DSA）照影提示大脑中动脉M1分枝血管显影不良；1h后CT灌注成像可见急性局部脑缺血病灶；72h后CT平扫可见低密度陈旧性局部脑缺血病灶。两例进行尸体解剖，大脑TTC染色呈阳性；存活动物均有不同程度的脑缺血症状与体征。结论用自体白色血栓可建立稳定的猴局部脑缺血模型，因该动物模型是目前最接近临床病例的模型，对脑卒中的发生发展机制的研究、诊断及治疗，特别是溶栓治疗有着切实的临床前期应用价值。 |
| 关 键 词： | 猴 自体血栓 大脑中动脉 脑缺血 |
| 文章编号： | 1005-8982（2005）24-3715-03 |
| 收稿时间： | 2005-03-17 |
| 修稿时间： | 2005-03-17 |
Establishment of local cerebral ischemia animal models in monkey by autologous pale thrombus |
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| WEI Ying,FENG Fei-ling,HUANG Zhi-hong,DENG Yan-xian,YU Jun-xiong,QIU Wei-jia,HE Zuo-kai,ZHOU Zhi-peng,GAN Rui-jing,WEI Ri-ming,RONG Ming-zhi.Establishment of local cerebral ischemia animal models in monkey by autologous pale thrombus[J].China Journal of Modern Medicine,2005,15(24):3715-3717,3720. | |
| Authors: | WEI Ying FENG Fei-ling HUANG Zhi-hong DENG Yan-xian YU Jun-xiong QIU Wei-jia HE Zuo-kai ZHOU Zhi-peng GAN Rui-jing WEI Ri-ming RONG Ming-zhi |
| Institution: | 1.Department of Pathophysiology, ;3.Department of Intervention,; 4.Department of Anesthesiology,; 5. Department of CT room,; 6.Institute of Techniques of Biological, Guilin Medical College, Guilin, Guangxi 541004, P.R.China,;2.Massachusetts General Hospital of Harvard University Charlestown MA 02129, USA |
| Abstract: | Objective] To discuss the function about autologous blood clots in making the animal model of cerebral ischemia. Method] Authors transmitted autologous blood clots into M1 branch of middle cerebral artery (MCA) of monkey by endovascular tiny injured repair. Results] The M1 branch of MCA developed not enough clear by digital subtraction angiography (DSA) after embolizated. One hour later, acute local ischemia focuses were seen by CT filling angiography and lower density old local ischemia focuses were seen 72h later using CT noncontrast scan. The two dead animals were immediately anatomized and cerebral TTC staining was found positive. The living animals had various degree behavior obstacle after coming to their senses. Conclusion] Establishment of this model is successful. It has fairly important value for the studying of stroke, especially in screening out potent thrombolytic drugs. |
| Keywords: | monkey autologous blood clots middle cerebral artery cerebral ischemia |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |