LAP+ Treg is a better biomarker than total Treg in viral myocarditis |
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| Authors: | Xinggang Wang Junbo Ge Ruizhen Chen |
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| Affiliation: | Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China |
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| Abstract: | ![]()
Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP+ Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg in CD4+ cells. Comparing with the previously recognized total Treg, LAP+ Treg was a better biomarker on myocardial inflammation. |
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| Keywords: | inflammation latency associated peptide (LAP+) regulatory T cells (Treg) viral myocarditis |
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