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Molecular characterization of Coxsackievirus A16 strains isolated from children with severe hand,foot, and mouth disease in Yunnan,Southwest China,during 2009-2015 |
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| Authors: | Ming Zhang Yilin Zhao Haihao Zhang Keqin Lin Hongbo Liu Jie Zhang Lisha Ding Xiaoqin Huang Zhaoqing Yang Shaohui Ma |
| Affiliation: | 1. The Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Kunming, China;2. The Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China |
| Abstract: | Coxsackievirus A16 (CV-A16) commonly causes mild symptoms, but severe diseases, such as aseptic meningitis, encephalitis, and even fatal cases, have been reported. Thirteen CV-A16 strains were isolated from patients with severe hand, foot, and mouth disease in Yunnan, Southwest China, from 2009 to 2015. Subgenotype B1a and B1b of CV-A16 were predominantly circulating the region with B1b the predominant strain in recent years. The mean rate of nucleotide substitution based on the VP1 gene sequence was 4.545 × 10 −3 substitution per site per year from 2009 to 2015. These results may help in understanding the genetic diversity of CV-A16 and develop a CV-A16 vaccine. |
| Keywords: | characterization complete genome Coxsackievirus A16 phylogenetic analysis |