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A cross-sectional serum investigation of a clustering hepatitis C virus infection in Southwest China |
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| Authors: | Haoran Peng Longyan Zhang Yue Feng Hailin Tang Zhenghan Luo Zhongtian Qi Xueshan Xia Ping Zhao |
| Affiliation: | 1. Department of Microbiology, Second Military Medical University, Shanghai Key Laboratory of Medical Biodefense, Shanghai, China Haoran Peng, Longyan Zhang and Yue Feng have authors contributed equally to this work.;2. Molecular Virology Laboratory, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China Haoran Peng, Longyan Zhang and Yue Feng have authors contributed equally to this work.;3. Department of Microbiology, Second Military Medical University, Shanghai Key Laboratory of Medical Biodefense, Shanghai, China;4. Molecular Virology Laboratory, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China |
| Abstract: | Serum samples were collected in a village with a clustering hepatitis C virus (HCV) infection. HCV antibody, HCV RNA loads, liver function indexes, HCV envelope antibody, and neutralizing activity were assessed. Among 851 adult sera, 342 samples were positive for anti-HCV. Of these positive samples, 254 (74.3%) were HCV RNA positive (≥800 copies/mL). None of the 69 children's sera were positive for HCV antibody or RNA. Among the HCV antibody positive sera, alanine aminotransferase, and aspartate aminotransferase levels increased with the higher virus loads, but decreased when virus loads were higher than 1 × 10 6 copies/mL. HCV envelope antibody and neutralizing antibody levels increased with viral load. |
| Keywords: | clustering infection hepatitis C virus (HCV) liver function indexes neutralizing antibodies |