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Hepatitis C virus genotypes in hemodialysis patients in Angola |
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| Authors: | Luis Filipe da Costa Marques Borges Mariano Gustavo Zalis Guilherme Santoro-Lopes Rafael Brandão Varella |
| Affiliation: | 1. Laboratory of Molecular Parasitology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;2. Laboratory of Molecular Parasitology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil Department of Preventive Medicine, Medicine School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;3. Department of Preventive Medicine, Medicine School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;4. Department of Microbiology and Parasitology, Universidade Federal Fluminense, Rio de Janeiro, Brazil |
| Abstract: | To our knowledge, there are no published data on hepatitis C virus (HCV) genotypes in Angola. This study aimed at assessing the distribution of HCV genotypes in seropositive hemodialysis patients in Luanda. Among 51 HCV-positive subjects included, viremia was detected in 27 (53%). HCV genotyping was performed by bidirectional sequencing of the 5'-untranslated region by the Sanger method. HCV genotype 4 was largely predominant (20 cases; 74%), followed by genotypes 1b (5 cases; 18.5%), 1a and 2 (one case each; 3.7%). These results suggest that the distribution of HCV genotypes in Angola is similar to that reported from other Central African countries. |
| Keywords: | Africa Angola epidemiology genotypes hemodialysis hepatitis C virus |