| 舒张性心力衰竭实验动物模型的研究进展 |
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| 引用本文： | 陈会花,章忱,吕嵘.舒张性心力衰竭实验动物模型的研究进展[J].实验动物与比较医学,2017,25(3):336-339. |
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| 作者姓名： | 陈会花 章忱 吕嵘 |
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| 作者单位： | 上海中医药大学病理教研室, 上海 201203,上海中医药大学病理教研室, 上海 201203,上海中医药大学病理教研室, 上海 201203 |
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| 基金项目： | 国家自然科学基金项目（编号：81373858）。 |
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| 摘 要： | 舒张性心力衰竭患者在并发高血压、糖尿病、心肌缺血和老龄化时可显著增加心衰的发病率，目前其潜在发病机制尚不完全清楚。随着我国人口老龄化的加剧，舒张性心力衰竭的患病率和死亡率明显上升，严重影响人们的生活质量和寿命。建立实验动物模型时尽量模拟临床发病诱因和特征，可以更真实地揭示疾病的发病机制或药物的作用机制。本文从舒张性心力衰竭的主要诱因重点综述构建舒张性心力衰竭实验动物模型的方法和各自的特点，为将来更多的研究舒张性心力衰竭发病机制的研究者提供依据。
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| 关 键 词： | 舒张性心力衰竭 动物模型 综述 |
| 收稿时间： | 2016/9/6 0:00:00 |
Advances in research of diastolic heart failure in experimental animal models |
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| CHEN Hui-hu,ZHANG Chen and LYU Rong.Advances in research of diastolic heart failure in experimental animal models[J].Laboratory Animal and Comparative Medicine,2017,25(3):336-339. |
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| Authors: | CHEN Hui-hu ZHANG Chen and LYU Rong |
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| Institution: | Department of Pathology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Department of Pathology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and Department of Pathology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | The risk factors of diastolic heart failure include among others:hypertension, diabetes, myocardial ischemia and aging. The underlying mechanisms for this cardiac complication are incompletely understood. With the increase of aging of the population, the prevalence and mortality of diastolic heart failure is rising gradually. It seriously affects the life quality and life span of people. In order to more truly reveal the underlying mechanisms of diastolic heart failure and to develope novel therapeutic strategies, the experimental animal models are extremely important. The present review focuses on providing an overview of the characteristics of these models for the growing number of investigators who seek to understand the pathology of diastolic heart failure. |
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| Keywords: | Diastolic heart failure Animal models Review |
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