慢性心力衰竭患者耐量运动训练后体内神经激素的变化

目的　研究耐量运动训练能否对慢性心力衰竭 (CHF)患者血浆中精氨酸血管加压素 (AVP) ,心钠素 (ANP) ,血管紧张素Ⅱ (AngⅡ )和醛固酮 (Aldo)水平有影响 ,延缓病程进展。方法　 12例CHF患者 (冠心病 ,心功能为Ⅱ～Ⅲ级 ,NYHA)隔天在监护下进行耐量运动训练 ,为期 12 0d。在进行耐量运动训练之前和之后 ,采用放射免疫法检测每一患者血浆中在静息状态下和极量平板运动后上述神经激素的水平。结果　经 12 0d的耐量运动训练后 ,静息状态下上述血浆神经激素水平较耐量运动训练前显著降低 (P <0 .0 5 ) ,但极量平板运动后与耐量运动训练前比较则差异无显著性意义 (P >0 .0 5 )。结论　耐量运动训练可降低CHF患者在静息状态下血浆AVP、ANP、AngⅡ和Aldo的水平 ,因此 ,可能有益于延缓CHF患者病程进展。

The changes of neurohormones after endurance exercise training in the patients with chronic heart failure

Objective To investigate the effects of endurance exercise training on plasma arginine vasopressin,atrial natriuretic peptide,angiotensinⅡ and aldosterone levels in chronic heart failure patients.Methods 12 chronic heart failure patients (coronary heart disease,New York Heart Association classⅡorⅢ) underwent supervised endurance exercise training on alternate days during a 120 days period.Before and after endurance exercise training,these neurohormones were measured by radioimmunoassay in resting condition and after peak treadmill exercise.Results After endurance exercise training for 120 days,the resting neurohormones levels were reduced significantly(P<0.05),but the plasma neurohormones levels after peak treadmill exercise did not change significantly(P>0.05).Conclusion The endurance exercise training could reduce the resting plasma arginine vasopressin,atrial natriuretic peptide,angiotensinⅡand aldosterone levels in chronic heart failure patients.The reduction in circulating neurohormones may delay the progress of chronic heart failure.