| 血根碱、白屈菜红碱离子对化合物的体外抗菌活性研究 |
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| 引用本文： | 康伟松,程辟,曾建国.血根碱、白屈菜红碱离子对化合物的体外抗菌活性研究[J].中南药学,2014(5):406-410. |
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| 作者姓名： | 康伟松 程辟 曾建国 |
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| 作者单位： | [1]湖南中医药大学湖南省植物功能成分利用协同创新中心,长沙410208 [2]湖南农业大学兽用中药资源与中兽药创制国家地方联合工程研究中心（湖南）,长沙410128 |
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| 基金项目： | 新药创制科技重大专项（No.2011ZX09401-309）; 国际科技合作项目（No.2011DFA32810） |
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| 摘 要： | 目的通过对血根碱离子对化合物、白屈菜红碱离子对化合物的体外抗菌活性研究,寻找具有潜在开发价值的抗菌药物。方法将血根碱、白屈菜红碱与多种有机酸制备成离子对化合物,采用试管稀释法和琼脂平板扩散法测定最低抑菌浓度(MIC)和最小杀菌浓度(MBC),结合抑菌圈实验,比较制备前后化合物的抗菌效果。结果血根碱与苯甲酸、乳酸、富马酸等有机酸形成离子对化合物之后抗菌活性增强,白屈菜红碱与乙酸、丙酸形成离子对化合物之后抗菌活性增强。结论一些结合小分子有机酸形成的离子对化合物显示出良好的抗菌效果,将生物碱制备为离子对化合物的方法为寻找新的抗菌药物提供了一种思路。
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| 关 键 词： | 离子对化合物 体外抗菌活性 血根碱 白屈菜红碱 |
In vitro antibacterial activity of sanguinarine and chelerythrine ion-pair compounds |
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| KANG Wei-song,CHENG Pi,ZENG Jian-guo.In vitro antibacterial activity of sanguinarine and chelerythrine ion-pair compounds[J].Central South Pharmacy,2014(5):406-410. |
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| Authors: | KANG Wei-song CHENG Pi ZENG Jian-guo |
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| Institution: | 1. National and Local Union Engineering Research Center for the Veterinary Herbal Medicine Resources and Initiative, Changsha 410208; 2. Hunan Co-Innovation Center for Utilization of Botanicals Functional Ingredients, Hunan University of Chinese Medicine, Changsha 410128) |
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| Abstract: | Objective To study the in vitro antibacterial activity of sanguinarine and chelerythrine ion-pair compounds to find antibacterial medicine with development potential. Methods The ion-pair compounds were obtained by the reactions of sanguinarine, chelerythrine and organic acids. The minimum inhibitory concentration and minimum bactericidal concentration were determined by tube dilution method, agar plate diffussion method and inhibition zone test to compare the antibacterial effect. Results The antibacterial activity of sanguinarine ion-pair compounds （combined with benzoic acid, lactic acid and fumaric acid, respectively） was better than that of sanguinarine. The antibacterial activity of chelerythrine ion-pair compounds （combined with acetic acid and propionic acid, respectively） was better than that of chelery thrine. Conclusion The ion-pair compounds of sanguinarine, chelerythrine combined with micromolecule organic acid show good anti-bacteria effect, which provides a method to search for new antibacterial compounds. |
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| Keywords: | ion-pair compound in vitro antibacterial activity sanguinarine chelerythrine |
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