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Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism |
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| Authors: | Sugihara Genichi Hashimoto Kenji Iwata Yasuhide Nakamura Kazuhiko Tsujii Masatsugu Tsuchiya Kenji J Sekine Yoshimoto Suzuki Katsuaki Suda Shiro Matsuzaki Hideo Kawai Masayoshi Minabe Yoshio Yagi Atsuko Takei Nori Sugiyama Toshiro Mori Norio |
| Institution: | Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan. |
| Abstract: | BACKGROUND: The mechanisms underlying the pathophysiology of autism are currently unknown. Given the role of hepatocyte growth factor (HGF) in brain development, we hypothesized that HGF plays a role in the pathophysiology of autism. In this study, we studied whether serum HGF levels are altered in subjects with high-functioning autism. METHODS: Using an enzyme-linked immunosorbent assay (ELISA), we measured serum levels of HGF in 17 male adults with high-functioning autism and age-matched 18 male healthy subjects. RESULTS: The serum levels (503.5+/-160.5 pg/mL (mean+/-SD)) of HGF in the subjects with high-functioning autism were significantly (Mann-Whitney U=34.0, p<0.001) lower than those (817.6+/-232.4 pg/mL (mean+/-SD)) of control subjects. However, there were no correlations between serum HGF levels and clinical variables in the patients. CONCLUSIONS: This study suggests that reduced HGF levels may play a role in the pathophysiology of high-functioning autism. |
| Keywords: | ADI-R Autism Diagnostic Interview-Revised ELISA enzyme-linked immunosorbent assay GABA γ-aminobutyric acid HGF hepatocyte growth factor IQ Intelligence Quotient MCHH Mother and Child Health Handbook uPAR urokinase plasminogen activator receptor Y-BOCS Yale–Brown Obsessive Compulsive Scale |
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