Effects of oral contraceptive steroids on enzymes of carbohydrate metabolism in extracts of human endometrium

Both the combined steroid contraceptive pill and the individual components influenced the activities of several enzymes of carbohydrate metabolism in extracts of human endometrium. Lactate dehydrogenase, for instance, was strongly inhibited by the combined pill and by individual steroid components of the pills. The effects of the steroids on the activities of the various enzymes were more pronounced in secretory-phase endometrium.The results suggest that oral contraceptive steroids may have a direct effect on carbohydrate metabolism in human endometrium.