高尿酸血症与体质量指数和脂代谢紊乱关系的临床研究

目的了解人群中高尿酸血症(HUA)的分布,探讨其与体质量指数(BMI)及脂代谢紊乱间的关系。方法对健康体检资料完整的10 000名体检者的血清尿酸水平及相关临床指标进行统计分析。按照血清尿酸水平(SUA)将人群分组,比较不同血清尿酸水平人群间脂代谢及BMI的差异,并按照体质量数分组,比较不同体质量指数人群间高尿酸血症检出率的差异。结果 (1)10 000名人群中,高尿酸血症(HUA)者2619例,占26.2%。按年龄分层,各年龄组间男性HUA检出率无明显差异(χ~2=7.637,P=0.177);女性50岁后HUA检出率较50岁前各年龄组显著增加(χ~2=48.190,P=0.000;χ~2=14.567,P=0.002;χ~2=1.874,P=0.599);(2)HUA组的胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白、体质量指数(BMI)水平均显著高于非高尿酸组,高密度脂蛋白水平显著低于非HUA组(P0.05);(3)HUA组高脂血症及超重、肥胖检出率显著高于非HUA组(P0.05);(4)超重及肥胖人群HUA检出率显著高于BMI正常人群,且随BMI升高HUA检出率增高(P0.05)。(5)Logistic回归显示:BMI、TC和TG是高尿酸血症发生的独立危险因素(P0.05)。结论肥胖和高脂血症是发生高尿酸血症的危险因素。

Clinical study of relationship between hyperuricemia and body mass index and dyslipidemia

Objective To investigate the distribution of hyperuricemia in population and explore the relation-ship between hyperuricemia and body mass index (BMI),lipid metabolism disorder.Methods Serum uric acid lev-el and relevant clinical indexes of 10 000 individuals with complete data for health physical examination were collected and performs a statistical analysis.The difference of lipid metabolism and BMI were analyzed by serum uric acid lev-el.Meanwhile the differences rate of HUA among populations with different BMI levels were compared.Results (1)The incidence of HUA in 10 000 population was 26.2%(n =2619),furthermore,when stratified by age,there was no significant difference among different age group in the male,,but the incidence of women was increased with age after 50 years;(2)In the HUA group,the level of serum TG,LDL and BMI were significantly higher than those in Non-HUA group,but the serum HDL level was lower than that in Non-HUA group;(3)The detected rates of over-weight,obesity and hyperlipidemia in HUA group were significantly higher than those in Non-HUA group;(4)The de-tected rate of HUA in overweight and obesity groups were significantly higher than that in normal BMI group,the rate was increased with BMI;(5)Logistic regression showed that BMI,serum TG and TC were independent risk factors of hyperuricemia.Conclusion Obesity and hyperlipidemia are the risk factors of hyperuricemia.