| 异体手移植的组织配型探讨 |
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| 引用本文： | 邵明,张震宇,杨群,张信英,于钟毓,毕郑钢,贾继峰,尚剑,张军,曹阳,杨成林,韩成龙,于方堤,富帛,孙闯.异体手移植的组织配型探讨[J].中国矫形外科杂志,2002,10(10):971-973. |
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| 作者姓名： | 邵明 张震宇 杨群 张信英 于钟毓 毕郑钢 贾继峰 尚剑 张军 曹阳 杨成林 韩成龙 于方堤 富帛 孙闯 |
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| 作者单位： | 哈尔滨医科大学第一临床医学院骨外科,150001 |
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| 摘 要： | 目的：研究组织配型在异体肢体移植中的基础作用和意义。方法：对患者和供者进行ABO血型和Rh血型，群体反应性抗体（PRA）检测及淋巴细胞毒性试验，测定人类白细胞抗原（HLA），结果：ABO血型（B－B）Rh血型相符，PRA和淋巴毒性交叉实验均为阴性，人类白细胞抗原（HLA）配型HLA－B，D，DR，DQ位点有4个抗原相合，手术后联合免疫抑制剂，移植双手成功，结论：理想的组织配型可避免异体手移植发生排斥反应，提高异体手移植成功率。
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| 关 键 词： | 异体手移植 异体移植 组织配型 排斥反应 淋巴细胞毒性试验 群体反应性抗体 白细胞抗原 |
| 文章编号： | 1005-8478(2002)10-0971-03 |
| 修稿时间： | 2002年1月16日 |
Discussion of Tissue Typing in Hand Allograft |
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| SHAO Ming,ZHANG Zhen yu,YANG Qun,et al..Discussion of Tissue Typing in Hand Allograft[J].The Orthopedic Journal of China,2002,10(10):971-973. |
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| Authors: | SHAO Ming ZHANG Zhen yu YANG Qun |
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| Institution: | SHAO Ming,ZHANG Zhen yu,YANG Qun,et al.Department of Orthopaedics,theFirst Affiliated Hospital of Harbin Medical University,Harbin 150001 |
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| Abstract: | Objective:To study the basal role and significance of tissue typing in human hand allotransplantation.Methods ABO,Rh,PRA and lymphocytotoxity text were tested in 2 transplant candidates with both hands defect and the potential donors.HLA were studied by serology(NIH standard)and molecular biology(PCR SSP).Results:One patient were matched with one ABO (B B)and Rh compatible,HLA A?B?DR?DQ sites half compatible donor,with negative PRA and lymphocytotoxity text.Immuno suppressive drugs were used after surgery and both hands recovered well.Iummune detect and skin biopsy shows no rejection.Conclusions:Ideal tissue compatibility is the premise to avoid rejection for hand allografting.Compatible ABO and Rh,negative lymphocytotoxity text is benificial,and low PRA level and high HLA compatibility would improve the survival rate. |
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| Keywords: | Allotransplantation Hand Tissue typing |
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