| 肾病综合征病人抗氧化功能的研究 |
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| 引用本文： | 张道友,叶任高.肾病综合征病人抗氧化功能的研究[J].皖南医学院学报,1996,15(3):207-209. |
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| 作者姓名： | 张道友 叶任高 |
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| 作者单位： | 附属弋矶山医院肾内科，中山医科大学肾脏研究所 |
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| 摘 要： | 为研究肾病综合征（ＮＳ）时抗氧化功能状况，我们测定３６例患者血超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）及维生素Ｅ，以及尿ＳＯＤ、ＭＤＡ。结果表明：ＮＳ患者血总ＳＯＤ、Ｃｕ－Ｚｎ－ＳＯＤ及维生素Ｅ水平明显低于正常对照组（分别为７６．２２±２７．４８μＵ／Ｌ比１０４．２０±１８．８０μＵ／Ｌ，Ｐ＜０．００１；２０．４０±２２．６３μＵ／Ｌ比６２．９９±１５．６０μＵ／Ｌ，Ｐ＜０．００１；６．６８±３．５２ｍｇ／Ｌ比１６．３８±１．０５ｍｇ／Ｌ，Ｐ＜０．００１）；尿ＳＯＤ及ＭＤＡ明显高于对照组（分别为：１１４．９８±３１．７３μＵ／Ｌ比８２．３４±２６．５０μＵ／Ｌ，Ｐ＜０．００１；３．９９±１．９８μｍｏｌ／Ｌ比２．６４±０．７８μｍｏｌ／Ｌ，Ｐ＜０．００１）．研究提示，ＮＳ时抗氧化功能减退，肾脏易遭受氧自由基损害。
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| 关 键 词： | 肾病综合征 维生素E 超氧化物歧化酶 丙二醛 |
RESEARCH OF ANTIOXIDATION STATE IN NEPHROTIC SYNDROME |
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| Zhang Daoyou,Ye Rengao,Ling Shanhong,et al.RESEARCH OF ANTIOXIDATION STATE IN NEPHROTIC SYNDROME[J].Acta Academiae Medicinae Wannan,1996,15(3):207-209. |
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| Authors: | Zhang Daoyou Ye Rengao Ling Shanhong |
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| Abstract: | Serum superoxide dismutase(SOD),Malonydialdehide(MDA),tocopherol,and urine SOD,MDA were measured from 36 cases of nephrotic syndrome in order to investigate antioxidation function state.The results show that the serum total SOD,Cu-Zn-SOD and tocopherol levels in these cases were lower significantly than those in the controls(76.22±27.48μU/Lvs 104.20±18.80μU/L,P<0.001;20.40±22.63μU/L vs 62.99±15.60μU/L,P<0.001;6.68±3.52mg/L vs 16.38±1.05mg/L,P<0.001;respectively),and the urine SOD and MDA levels were higher significantly than those of the controls(114. 98±31.73μU/L vs 82.34±26. 50μU/L,P<0.001;3.99±1.98μmol/L vs 2.64±0.78μmol/L,P<0.001;respectively).The study suggests that antioxidation function in nephrotic syndrome is decreased,so the kidneys are liable to be injured by oxygen free radicals. |
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| Keywords: | Nephrotic syndrome vitamine E Superoxide dismutase Malonydialdehide |
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