| 丹参对胃溃疡大鼠血清一氧化氮含量和胃粘膜表皮生长因子受体表达的影响 |
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| 引用本文： | 魏岳斌,李国成.丹参对胃溃疡大鼠血清一氧化氮含量和胃粘膜表皮生长因子受体表达的影响[J].中国中西医结合消化杂志,2001,9(4):211-212. |
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| 作者姓名： | 魏岳斌 李国成 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院中西医结合科, |
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| 摘 要： | 目的：观察胃溃疡大量血清一氧化氮（NO）含量，溃疡周围粘膜上表皮生长因子受体（EGFR）表达，研究其与丹参改善微循环及促进胃粘膜上皮细胞增生之间的关系，进而阐明丹参抗胃溃疡的可能机制。方法：大鼠30只。随机分为对照组、模型组和丹参组，采用硝酸还原酶法测定动物血清NO含量，免疫组织化学方法测定胃粘膜EGFR表达，结果：丹参组NO含量较模型组显著升高，EGFR表达亦较模型组显著增强（P＜0．05）。结论：丹参可能通过NO、EGFR等介导改善胃溃疡大胃粘膜微循环及促进胃粘膜上细胞增生，从而发挥抗胃溃疡作用。
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| 关 键 词： | 丹参 胃溃疡 一氧化氮 表皮生长因子受体 中医药疗法 中药 |
Effect of Danshen on Content of Nitric Oxide in Serum and Expression of Epidermal Growth Factor Receptor in Gastric Mucosa of Rats with Gastric Ulcer and Its Possible Mechanism |
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| WEI Yuebin,LI Guocheng.Effect of Danshen on Content of Nitric Oxide in Serum and Expression of Epidermal Growth Factor Receptor in Gastric Mucosa of Rats with Gastric Ulcer and Its Possible Mechanism[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2001,9(4):211-212. |
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| Authors: | WEI Yuebin LI Guocheng |
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| Institution: | WEI Yuebin,LI Guocheng Department of Combination of TCM and Western Medicine,Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | |
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| Keywords: | Danshen Gastric ulcer Nitric oxide Epidermal growth factor receptor |
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