A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community |
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| Authors: | Basilua Andre Muzembo Yasunori Nagano Masamitsu Eitoku Nlandu Roger Ngatu Tomomi Matsui Sabah Asif Bhatti Ryoji Hirota Kenji Ishida Narufumi Suganuma |
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| Institution: | 1. Division of Social Medicine, Department of Environmental Medicine, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nangoku-shi, Kochi, 783-8505, Japan
2. Department of Orthopedics, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nangoku-shi, Kochi, 783-8505, Japan
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| Abstract: | Objectives The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. Methods This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. Results Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. Conclusions Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle. |
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| Keywords: | Oxidative stress Handgrip strength Cross-sectional study Older persons Lifestyle |
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