| 东亚钳蝎毒及其成分抗癫痫肽对心脏和血管的作用 |
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| 引用本文： | 刘崇铭,高殿振,周新华,张桂范,崔焱.东亚钳蝎毒及其成分抗癫痫肽对心脏和血管的作用[J].沈阳药科大学学报,1987(2). |
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| 作者姓名： | 刘崇铭 高殿振 周新华 张桂范 崔焱 |
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| 作者单位： | 沈阳药学院生理教研室，沈阳药学院生理教研室，沈阳药学院生化教研室，沈阳药学院药学系，沈阳药学院药学系 毕业专题学生，毕业专题学生 |
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| 摘 要： | 本文报告河北产东亚钳蝎(Buthus martensii Karsch)毒及用柱层析法从粗毒中纯化的抗癫痫肽对心脏、血管的作用。实验结果证明蝎毒能使麻醉免LVP、左室dp/dt升高、心率稍减慢;心得安能对抗蝎毒升高LVP和dp/dt的作用。抗癲痫肽对LVP、dp/dt、心率的影响都不明显。蝎毒使离体豚鼠心脏收缩张力增强,心率减慢,并呈现频繁的心律不齐。心得安能对抗蝎毒增强心脏收缩张力的作用,但不能消除心律不齐。抗癫痫肽使心肌收缩张力下降,心率加快,同时也引起心律不齐。蝎毒能引起兔主动脉条明显收缩,作用强度约为NE的1/5,在蝎毒作用的基础上,妥拉苏林使收缩曲线升高,心得安使曲线降低。抗癲痫肽使兔主动脉条轻微松弛。用光电容积搏动法实验,蝎毒和抗癲痫肽都能使小鼠末稍血管收缩。
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| 关 键 词： | 东亚钳蝎毒 抗癫痫肽 LVP LVdp/dt 心肌张力 主动脉条收缩 尾血管光电容积搏动 |
EFFECTS OF THE VENOM OF BUTHUS MARTENSII KARSCH AND ANTIEPILEPSY PEPTIDE(AEP)ON THE HEART AND BLOOD VESSELS |
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| Liu Chongming Gao Dianzhen Zhou Xinhua Zhang Guifan Cui Yan.EFFECTS OF THE VENOM OF BUTHUS MARTENSII KARSCH AND ANTIEPILEPSY PEPTIDE(AEP)ON THE HEART AND BLOOD VESSELS[J].Journal of Shenyang Pharmaceutical University,1987(2). |
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| Authors: | Liu Chongming Gao Dianzhen Zhou Xinhua Zhang Guifan Cui Yan |
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| Institution: | Liu Chongming Gao Dianzhen ~*Zhou Xinhua Zhang Guifan Cui Yan Department of Physiology ~*Department of Biochemistry |
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| Abstract: | Reported in this paper are the effects of the venom collected from scorpions of Buthus martensii Karsch from Hebei Province, and AEP, isolated from the venom, on the heart and blood vessels.
In our experiments LVP, LV dp/dt of anesthetized rabbits were increased by the venom and the heart rate of the rabbits was decraesed slightly.The increase of LVP, LV dp/dt caused by the venom could be counteracted by propranolol. The effects of AEP on LVP, LV dp/dt and heart rate were insignificant. The venom increased the contracting tension of a guinea pig's heart, decreased the heart rate and induced arrhythmia.The propranololin counteracted the contracting tension of the heart,but could not get rid of arrhythmia.
Compared with that caused by the same dosage of NE the contraction of the rabbit's aortic strips by venom was 1/5 in strength.On the basis of venom action tolazoline made the contraction curve go upwards while propranolol did the opposite.
Photoelectric plethysmograph tests showed that contractions of the blood vessels in the tails of mice anethetized were effected by venom and AEP as well. |
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| Keywords: | Venom of Buthus martensii Karsch Anti-epilepsy peptide(AEP) LV dp/dt Contracting tension of heart Contraction of strips of aorta Photoelectric plethysmograph of mice's tail |
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