妊高征肾病患者血浆Hcy和血清FA、Vit B12检测的临床意义

目的:探讨了妊高征肾病患者血浆同型半胱氨酸(Hcy)和血清叶酸(FA)、维生素B12(Vit B12)水平的变化及临床意义.方法:应用放射免疫分析和免疫法测定了32例妊高征肾病和70例无肾病组及35名正常孕妇血浆Hcy和血清FA、Vit B12水平的变化.结果:妊高征肾病组和无肾病组血浆Hcy水平均非常显著地高于正常孕妇组(P＜0.01),而FA、Vit B12水平则显著地低于正常孕妇组(P＜0.01),妊高征肾病组与无肾病组亦有显著性差异(P＜0.01).结论:测定妊高征患者血浆Hcy和血清FA、Vit B12水平的变化对其病情和预后判断均具有重要的临床价值.

Clinical Significance of Determination of Changes of Plasma Hcy and Serum Folic Acid and Vitamin B12 Levels in Patients with Pregnancy Induced Hypertension Complicated with Nephr Opathy

Objective To investigate the clinical significance of changes of plasma homocysteine(Hcy),serum folic acid and vitamin B12 levels in patients with pregnancy induced hypertension(PIH) complicated with nephropathy.Methods Plasma Hcy levels was measured with immuno chemistry and serum folic acid and vitaminB12 levels were detected with RIA in 32 pregnant women with PIH complicated with nephrophy and 70 pregnant women with PIH but without nephrophy and 35 pregnant women without PIH(as controls).Results The plasma Hcy levels in patients with PIH were significantly higher than those without(i.e.controls)(P<0.01),while the serum folic acid,vitaminB12 levels decreased markedly(P<0.01).Among the pregnant women with PIH,plasma Hcy levels were significantly higher and serum folic acid,B12 levels were significantly lower in the patients complicated with nepropathy than those in patients without nephropathy(P<0.01).Conclusion Determination of plasma Hcy and serum folic acid and vitaminB12 levels is clinically useful in the management in patients with pregnancy induced hypertension complicated with nephropathy.