| 绞股蓝总皂甙对小鼠产生白细胞介素2(IL-2)的增强效应 |
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| 引用本文： | 刘倩娴,梁旻若,陈妙欢,万幸,季健民.绞股蓝总皂甙对小鼠产生白细胞介素2(IL-2)的增强效应[J].中药药理与临床,1993(5). |
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| 作者姓名： | 刘倩娴 梁旻若 陈妙欢 万幸 季健民 |
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| 作者单位： | 广州中医学院微生物学教研室，广州中医学院微生物学教研室，广州中医学院微生物学教研室，广州中医学院微生物学教研室，广州中医学院微生物学教研室 广州 510407，广州 510407，广州 510407，广州 510407，广州 510407 |
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| 摘 要： | 大黄脾虚模型小鼠IL-2活性比正常小鼠明显降低;绞股蓝总皂甙10～80mg/L以及100～200mg/kg在体外、体内可协同ConA使正常小鼠脾细胞产生之IL-2明显提高;10～40mg/L和50～200mg/kg在体外、体内也能协同ConA使大黄脾虚模型小鼠低下的IL-2活性提高,并恢复至接近正常水平。绞股蓝总皂甙能使脾虚小鼠低下的IL-2提高的实验结果进一步提示IL-2可能与机体的“正气”和“脾”的本质存在某种内在联系,也可能是中医“脾气”的免疫学物质基础之一。
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| 关 键 词： | 绞股蓝总皂甙 脾虚 白细胞介素2 |
Enhacing Effect of Gypenoside on the Production of Interleukin-2 (IL-2) in Mice |
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| Liu Qianxian Liang Minruo Chen Miaohuan Wan Xing Ji Jianmin.Enhacing Effect of Gypenoside on the Production of Interleukin-2 (IL-2) in Mice[J].Pharmacology and Clinics of Chinese Materia Medica,1993(5). |
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| Authors: | Liu Qianxian Liang Minruo Chen Miaohuan Wan Xing Ji Jianmin |
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| Abstract: | An experiment was made to study the effect of Gypenoside on interleukin-2 (IL-2) production in normal mice and Rhubarb-inducing Pi-asthenia model mice in order to understand the relationship between Gypenoside and IL-2. The results showed that: 1) Gypenoside (10-80mg/L in vitro, 100-200mg/kg in vivo) could increase IL-2 production induced by ConA from normal murine spleen cell ; 2) IL-2 production in Pi-asthenia mice was lower than that in normal mice which could be enhanced to normal level by ConA and Gypenoside (10-40mg/L in vitro, 50-200mg/kg in vivo) . It suggested that IL-2 may be related to "healthy Qi" and Pi, and also one of the immunological substantial basis of Pi-Qi in traditional Chinese medicine. |
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| Keywords: | GYPENOSIDE Pi-ASTHENIA INTERLEUKIN-2 |
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