| 止消通脉宁对糖尿病大鼠肾脏胶原非酶糖化的影响 |
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| 引用本文： | 徐丽梅,刘连起,于秀辰.止消通脉宁对糖尿病大鼠肾脏胶原非酶糖化的影响[J].北京中医药大学学报,2000,23(3):24-26. |
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| 作者姓名： | 徐丽梅 刘连起 于秀辰 |
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| 作者单位： | 北京中医药大学,北京,100029 |
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| 基金项目： | “九五”国家科技攻关项目课题!(No.96 90 6 0 9 0 8) |
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| 摘 要： | 采用STZ糖尿病大鼠模型 ,在 6 ,12周分别观察肾脏组织发生非酶糖基化的情况 ,并观察止消通脉宁及氨基胍的作用。结果发现不同病程STZ糖尿病大鼠肾脏组织的胶原含量和非酶糖基化早期产物 (5 HMF)及胶原相联荧光值均明显高于正常对照组 ,并随病程的延长而增高。止消通脉宁有阻断肾脏组织非酶糖基化的作用 ,而对 5 HMF的作用优于氨基胍。说明高糖环境下肾脏组织可发生非酶糖基化 ,止消通脉宁有抑制肾脏组织非酶糖基化的作用 ,是其防治糖尿病肾病的作用机理之一
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| 关 键 词： | 糖尿病大鼠 非酶糖基化 5-HMF胶原相联荧光值 止消通脉宁 |
Effect of ZhiXiaoTongMaiNing on Nonenzymatic Glycosylation of Renal Tissue in Diabetic Rats |
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| Xu Limei,Liu Lianqi,Yu Xiuchen.Effect of ZhiXiaoTongMaiNing on Nonenzymatic Glycosylation of Renal Tissue in Diabetic Rats[J].Journal of Beijing University of Traditional Chinese Medicine,2000,23(3):24-26. |
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| Authors: | Xu Limei Liu Lianqi Yu Xiuchen |
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| Abstract: | To investigate the change of nonenzymatic glycosylation and the blocking effect of ZhiXiaoTongMaiNing (ZXTMN) in streptozotocin (STZ) induced diabetic rats. The content of collagen and 5 HMF and collagen related fluorescence in renal cortex were determined. Results: After 6,12 weeks of diabetic rats, the content of collagen and 5 HMF and collagen related fluorescence in renal cortex were higher than that normal control group. 5 HMF in ZXTMN group were lower than in aminoguanidine group. Conclusion: ZXTMN has prevention effect of nonenzymatic glycosylation of renal tissue in diabetes. |
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| Keywords: | Nonenzymatic glycosylation collagen related fluorescence 5 HMF ZhiXiaoTongMaiNing |
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