血清瘦素水平及体质指数与乳腺癌发生的相关性研究

  目的 探讨血清瘦素水平及体质指数与乳腺癌发生的相关性，为乳腺癌的防治寻找科学依据。方法 收集术前乳腺癌患者90例，乳腺良性疾病患者32例，健康对照103例血清，采用放射免疫分析法测定瘦素水平，并进行体质指数的测量与计算。采用SPSS软件包进行统计学处理。结果 乳腺癌组血清瘦素水平与体质指数明显高于乳腺良性疾病和健康对照组，差异均具有统计学意义（P＜0.01）；三组人群瘦素水平与体质指数均呈正相关，相关系数分别为0.327（P＜0.001），0.416（P＜0.001），0.525（P＜0.001）；Logistic回归分析，血清瘦素水平的升高是乳腺癌发生的危险因素，OR值为1.14（95 %CI：1.076 ~ 1.209）。结论 血清瘦素水平、体质指数升高可能与乳腺癌发生有关。

Relationship between serum leptin level BMI and breast cancer incidence

Objective To investigate the relationship of serum leptin concentration, body mass index(BMI) and breast cancer. Methods Blood samples were collected from 90 patients with breast cancer, 30 patients with breast benign disease selected from Shanxi Cancer Hospital, 103 healthy controls. Serum leptin were measured by radioimmunoassay (RIA) Results The serum leptin concentration and BMI in breast cancer group were significantly higher than in the breast benign disease and healthy control (P < 0.01, respectively). There was no significant difference of the serum leptin between postmenopausal and premenopausal women with breast cancer and breast benign disease(P > 0.05). Multiple logistic regression analyses observed a significant association between serum leptin and breast cancer incident. (OR leptin=1.14, 95 % confidence interval CI:1.076 to 1.210). Conclusion Our results suggested that the increased serum leptin levels may be the risk factors. The BMI was significantly higher in breast cancer group, and was positively correlated with leptin level, but further research is needed to confirm these findings and to clarify the underlying mechanisms involved.