厄贝沙坦与依那普利治疗老年人轻中度高血压的疗效比较

目的比较厄贝沙坦与依那普利治疗老年人轻、中度高血压的疗效和不良反应。方法 110例老年人轻、中度高血压患者随机分为厄贝沙坦组(A组)56例、依那普利组(B组)54例。两组患者未曾接受降压治疗或已停用降压药物2周以上。A组服用厄贝沙坦150～300mg,1次/d,B组服用依那普利2.5～20mg,2次/d;疗程均为4周。观察两组治疗前后血压变化和不良反应发生情况。结果两组患者治疗后血压均显著降低(P0.01),组间降压幅度无明显统计学差异(P0.05),两组总有效率无显著差异(P0.05),不良反应发生率厄贝沙坦组明显低于依那普利组(P0.01)。结论两种药物治疗老年人轻、中度高血压均有明显疗效,厄贝沙坦不良反应少,耐受性和安全性好,更适合老年患者。

Comparison of Curative Effects of Irbesartan and Enalapril in Treatment of Elderly Patients with Mild to Moderate Hypertension

Objective To compare the curative effects and the adverse reactions of irbesartan and enalapril in the treatment of elderly patients with mild to moderate hypertension. Methods All 110 cases of elderly patients（57 men and 53 women） with mild to moderate hypertension were randomized to treat with irbesartan 150-300mg once daily（Group A, 29 men and 27 women） or enalapril 2.5 -20mg twice daily（Group B, 28 men and 26 women）for 4 weeks. The blood pressure changes and the adverse reactions were observed at the baseline and the end. Results Both drugs reduced clinic BP（P〈0.01）, with no significant difference in the pressure decrease（P〉0.05）. After 4 weeks,the total effectiveness was 82.1% in Group A and 77.8% in Group B,with no significant difference between two groups（P〉0.05）. Adverse effect rate in the irbesartan-treated group（5.4%） was much lower than that of another group （24.1%）（P〈0.01）. Conclusion Both irbesartan and enalapril can significantly reduce BP in elderly patients with mild to moderate hypertension. Irbesartan shows fewer adverse effects,better tolerated and safety than those of enalapril in the treatment of elderly hypertensive patients.