贝前列素钠治疗对早期糖尿病肾病患者血清胱抑素C及尿微量清蛋白的影响

目的观察贝前列素钠治疗对早期糖尿病肾病(DN)患者血清胱抑素C(Cys-C)及尿微量清蛋白(MAU)的影响。方法选取75例2型糖尿病患者,其中27例为单纯糖尿病患者,48例为早期DN患者。将早期DN患者随机分为常规治疗组和贝前列素钠治疗组,仅给予常规治疗,后者再加用贝前列素钠治疗。观察患者治疗前后血清Cys-C、尿MAU及尿清蛋白排泄率(UAER)的变化。结果早期DN患者血清Cys-C水平显著高于单纯糖尿病患者,差异有统计学意义(P<0.01)。治疗后,贝前列素钠治疗组患者血清Cys-C、尿MAU及UAER较常规治疗组显著降低,差异有统计学意义(P均<0.05)。结论早期DN患者即存在血清Cys-C水平升高;贝前列素钠治疗能显著降低早期DN患者血清Cys-C及尿MAU水平,对早期DN有保护作用。

Effects of Beraprost Sodium on Serum Cystatin C and Urinary Microalbumin in Patients with Early Diabetic Nephropathy

Objective To observe the effect of beraprost sodium on serum cystatin C(Cys-C) and urinary microalbumin(MAU) in patients with early diabetic nephropathy(DN).Methods 75 patients with type 2 diabetes mellitus were involved into the study,among which 27 cases were diabetic patients without DN and 48 cases were diabetic patients with early DN.The early DN patients were randomly divided into routine treatment group and beraprost sodium treatment group.The former group was given routine treatment while the latter group was given additional beraprost sodium.The changes of Cys-C,urinary MAU and urinary albumin excretion rate(UAER) were observed before and after the treatment.Results The level of serum Cys-C in early DN patients was significantly higher than that of the diabetic patients without DN(P<0.01).After treatment,the levels of Cys-C,urinary MAU and UAER in beraprost sodium treatment group were significantly lower than those of the routine treatment group(P<0.05).Conclusion Patients with early DN have elevated serum Cys-C level.Beraprost sodium can effectively reduce the levels of Cys-C and urinary MAU in early DN patients and has protective effect on DN.