不同职业人群脂肪肝患病情况及相关因素分析

目的通过对不同职业人群各年龄段脂肪肝患病情况及相关危险因素进行分析,探讨不同职业人群脂肪肝流行情况及相关危险因素。方法选择体检中医务人员、高校教师、干警、机关工作人员共11 044例为研究对象,根据职业进行分组,分析不同职业人群脂肪肝患病情况,根据是否患脂肪肝分为脂肪肝组及非脂肪肝组,对脂肪肝相关危险因素进行分析。结果人群脂肪肝患病率为36.46%,男性患病率(45.41%)高于女性(26.49%),男性40～60岁患病率较高,女性50岁之后患病率开始上升,60岁后患病率较高;不同职业女性脂肪肝患病率无明显不同,而40～60岁的不同职业男性脂肪肝患病率不同,机关工作人员患病率高于其他职业;年龄、体质指数、舒张压、尿素氮、尿酸、空腹血糖、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、丙氨酸氨基转移酶、γ-谷氨酰基转移酶、天门冬酸氨基转移酶/丙氨酸氨基转移酶、乙肝表面抗体与脂肪肝的发生有相关性,其中高密度脂蛋白胆固醇和乙肝表面抗体是保护性因素。结论男性脂肪肝重点防治年龄为40～60岁,女性为绝经期后;生活方式对脂肪肝的发生有明显影响,健康的生活方式可降低脂肪肝的患病风险;脂肪肝患者主要为肝细胞轻、中度损伤,血脂、血压、血糖、血尿酸、体质指数的控制可减少脂肪肝的发生。

Analysis on Prevalence and Related Factors of Fatty Liver in Different Occupational Groups

Objective Research on epidemic situation of fatty liver and related risk factors in different occupational groups by analyzing the prevalence and related risk factors of fatty liver in different occupational groups at different ages.Methods 11 044 people from namely medical personnel,university teachers,police officers and government cadres,were selected as objects of the research to analyze the prevalence of fatty liver by dividing them into groups according to different occupations,and to analyze risk factors related to fatty liver by dividing them into fatty liver group and non-fatty liver group according to whether they have suffered from fatty liver or not.Results The prevalence rate of fatty liver is 36.46%,among which the prevalence rate of male patients was 45.41%,while for female it was 26.49%.There was a high prevalence rate among males between 40 to 60 years old,while for females it starts to increase since 50 years old and reaches a higher rate since 60 years old.There was a slight difference in the prevalence rate of fatty liver among females of different occupations,but it differs among males of different occupations between 40 to 60 years old,and those from governmental offices occupies a higher prevalence rate than the others.There is a correlation between the occurrence of fatty liver and ages,body mass index,diastolic pressure,urea nitrogen,uric acid,fasting blood-glucose,triglycerides,high density lipoprotein cholesterol,low density lipoprotein cholesterol,alanine aminotransferase,γ-glutamyltransfarase,AST/ALT and hepatitis B virus surface antibody,in which the high density lipoprotein cholesterol and hepatitis B virus surface antibody are protective factors.Conclusion For male patients,the key prevention and treatment age period for fatty liver is from 40 to 60 years old,while for female patients,it is after menopause.Besides,lifestyle has a significant influence on the occurrence of fatty liver,and a healthy lifestyle can effectively decrease the prevalence of fatty liver.For fatty liver patients,they are mainly suffering from slight and medium injury in hepatocyte,so by controlling the blood fat,blood pressure,blood sugar,uric acid and body-mass index will decrease the occurrence of fatty liver.