多重耐药铜绿假单胞菌的临床感染分布及耐药性分析

目的了解铜绿假单胞菌在临床感染中的分布,并进行耐药性分析,为临床治疗提供依据。方法采用美国MicroScan Walkway-40全自动微生物分析仪及配套复合板进行鉴定及药敏试验;回顾性统计分析258株铜绿假单胞菌的来源、感染科室分布及耐药情况。结果分离的258株铜绿假单胞菌主要来源于下呼吸道痰标本,占63.2%。主要集中在呼吸科、神经外科、ICU以及烧伤科等。铜绿假单胞菌对头孢噻肟和头孢曲松的耐药率均>45%,对环丙沙星、庆大霉素、左氧氟沙星和妥布霉素的耐药率均>30%,出现了一定比例的亚胺培南耐药菌株,耐药率为6.6%。结论铜绿假单胞菌对多种抗生素均产生了不同程度的耐药性,多重耐药性明显,临床应加强其耐药性监测及针对性管理措施,减少耐药菌的产生和扩散。

Distribution of Clinical Infection and Drug Resistance Analysis of Multi-drug Resistant Pseudomonas Aeruginosa

Objective To understand the distribution of Pseudomonas aeruginosa in clinical infections,and analyse the drug resistance so as to provide a basis for clinical treatment.Methods The MicroScan Walkway-40 automated microbial analyzer made in the United States and supporting composite plate were used for identification and susceptibility testing;and retrospective statistical analysis of 258 strains of Pseudomonas aeruginosa was conducted about the source of specimen,distribution of infection department and drug resistance.Results The 258 strains of Pseudomonas aeruginosa were mainly derived from lower respiratory tract sputum specimens,accounting for 63.2%.The infection was mainly concentrated in respiratory,neurological surgery,ICU and burn departments.The resistance rate os Pseudomonas aeruginosa to cefotaxime and ceftriaxone was more that 45%,to ciprofloxacin,gentamicin,levofloxacin,and tobramycin was more than 30%.There has been a certain percentage of imipenem resistant strains,with resistance rate of 6.6%.Conclusion Pseudomonas aeruginosa presents a high resistance against multiple antibiotics to a certain degree,with obviously multi-drug resistance.So surveillance on drug resistance and targeted management measures should be strengthened to reduce the generation and diffusion of drug-resistant bacteria.