Reaction of indomethacin with singlet molecular oxygen |
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Authors: | Richard S. Bodaness Phillip C. Chan |
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Affiliation: | Department of Biochemistry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, U.S.A. |
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Abstract: | Singlet molecular oxygen is a highly reactive species and is capable of disrupting cell membranes and collagen. It may also play a role in the synthesis of prostaglandins. We show here that indomethacin can react with singlet molecular oxygen and suggest that part of the anti-inflammatory action of this drug may stem from its ability to scavenge singlet oxygen. |
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