|
|||||
|
|
| D-半乳糖衰老模型大鼠肝脏形态学及抗氧化能力变化的研究 | |
| 引用本文： | 徐辉,魏晓东,欧芹,王景涛,辛红. D-半乳糖衰老模型大鼠肝脏形态学及抗氧化能力变化的研究[J]. 黑龙江医药科学, 2005, 28(5): 26-27 |
| 作者姓名： | 徐辉 魏晓东 欧芹 王景涛 辛红 |
| 作者单位： | 佳木斯大学基础医学院 黑龙江佳木斯154007(徐辉，魏晓东，欧芹，王景涛)，天津市人民医院 天津300121(辛红) |
| 摘 要： | 目的:观察D-半乳糖致衰大鼠肝脏形态学改变及氧化水平和抗氧化能力的变化。方法:采用D-半乳糖所致衰老模型大鼠,做肝组织HE染色光镜观察,测定C a2 -ATP酶活性,肝线粒体M DA含量、PLA2活性。结果:衰老模型大鼠肝组织形态学发生明显变化,肝脏C a2 -ATP酶活性显著降低(P<0.01),肝线粒体M DA含量、PLA2活性显著升高(P<0.01)。结论:D-半乳糖致衰大鼠可作为研究衰老的模型。 |
| 关 键 词： | D-半乳糖 衰老模型 形态学 抗氧化能力 大鼠 |
| 文章编号： | 1008-0104-(2005)05-0026-02 |
| 修稿时间： | 2005-09-13 |
Liver morphology of and anti-oxidation capability in aging rat model induced by D-gal |
|
| XU Hui,WEI Xiao-dong,OU Qin,WANG Jing-tao,XIN Hong. Liver morphology of and anti-oxidation capability in aging rat model induced by D-gal[J]. Heilongjiang Medicine and Pharmacy, 2005, 28(5): 26-27 | |
| Authors: | XU Hui WEI Xiao-dong OU Qin WANG Jing-tao XIN Hong |
| Affiliation: | XU Hui~1,WEI Xiao-dong~1,OU Qin~1,WANG Jing-tao~1,XIN Hong~2 |
| Abstract: | Objective: To investigate the liver morphology and the oxidation and anti-oxidation capability of aging rat model induced by D-gal.Methods: We used the aging model rat induced by D-gal as research sample,and observed the hepatic tissue HE staining under light microscope.We measured the Ca~(2 )-ATPase activity in rat liver and determined the MDA content,PLA_2 activity of rat liver mitochondria.Results: The liver morphology was markedly changed and Ca~(2 )-ATPase activity was obviously decreased(P<0.01)and the MDA content and PLA_2 activity were markedly increased((P<0.01))in the aging rat model.Conclusion: The aging rat model induced by D-gal can be used as the model for aging research. |
| Keywords: | D-gal aging model morphology anti-oxidation capability rat |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |