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Immunohistochemical analysis of cyclooxygenase‐2 and brain fatty acid binding protein expression in grades I‐II meningiomas: Correlation with tumor grade and clinical outcome after radiotherapy |
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| Authors: | Hyun‐Cheol Kang Il Han Kim Charn Il Park Sung‐Hye Park |
| Affiliation: | 1. Department of Radiation Oncology, Seoul National University College of Medicine, , Seoul, Korea;2. Department of Radiation Oncology, Dongnam Institute of Radiological and Medical Sciences, , Busan, Korea;3. Department of Cancer Research Institute, Seoul National University College of Medicine, , Seoul, Korea;4. Institute of Radiation Medicine, Medical Research Center, Seoul National University, , Seoul, Korea;5. Department of Pathology, Seoul National University College of Medicine, , Seoul, Korea |
| Abstract: | This study was done to evaluate the association of cyclooxygenase 2 (COX‐2) and brain fatty acid binding protein (BFABP) with tumor grade and outcome of grades I‐II meningiomas treated with radiotherapy. From 1996 to 2008, 40 patients with intracranial grades I‐II meningiomas were treated with radiotherapy. Immunohistochemical staining for COX‐2 and BFABP were performed on formalin‐fixed paraffin‐embedded tissues. COX‐2 expression was significantly associated with BFABP status and both COX‐2 (P < 0.01) and BFABP (P = 0.01) expression were stronger in the grade II meningiomas than in grade I tumors. Among the clinicopathologic factors, age and COX‐2 status were prognostic in progression‐free survival. Patients with moderate or strong COX‐2 expression had worse outcome than those with negative or weak COX‐2 expression (P = 0.03) after controlling for potential confounders. Our results suggest that the molecular biomarker COX‐2 has prognostic significance in intracranial grades I‐II meningiomas following radiotherapy. |
| Keywords: | brain fatty acid binding protein cyclooxygenase‐2 immunohistochemistry meningioma radiotherapy |