丹参及其有效成份对低氧性肺血管收缩作用研究

实验应用离体豚鼠肺动脉研究丹参及其有效成份丹参素对低氧性肺血管收缩（ＨＰＶ）的作 用。用９５％Ｎ２＋５％ＣＯ２取代９５％Ｏ２＋５％ＣＯ２以诱发（ＨＰＶ）。采用自体配对设计，每一药物试验组含６ 对肺动脉环，每对分为对照组和用药组。复方丹参注射液，（５～４０ｍｇ／ｍｌ），丹参注射液（２０～８０ｍｇ／ｍｌ） 和丹参素（１．２５～５ｍｇ／ｍｌ）均能抑制ＨＰＶ，且剂量越大，抑制作用越强。比较等同剂量的三种药物的作 用：丹参素作用最强，其次为复方丹参注射液。结果表明，丹参能拮抗ＨＰＶ；丹参对ＨＰＶ的抑制作用主 要由丹参素产生。复方丹参注射液的作用优于丹参注射液，可能是因为前者含有降香的作用。

Effect of salvia miltiorrkiza and its effective composition on hypoxic pulmonary vaoconstriction in guinea pig.

The experiment was designed to investigate the effect of salvia miltiorrhiza (Danshen ) and its effective composition, phenyl lactic acid (Danshensu )on the hypoxic pulmonary vasoconstriction (HPV). Acute hypoxia was induced by replacing mixed gas 95%O2 5 %CO2 with 95%N2 5 %CO2. Hypoxic pulmonary vasoconstriction was diminished by injectic Danshen, Injectic Danshen compound and Danshensu with concentration dependently. Tile effect of Danshensu was the most,and Injectic Danshen Co was second by comparison. The results suggested that Danshen can antagonist HPV which was mainly produced by Danshensu, one of the effective composition of Danshen,and that more potent inhibitory action on HPV was by Injectio Danshen compound compared with Injectio Danshen,and this may be related to the addition of Dalbergia odorifera , the other composition of Injectic Danshen compound.