高渗氯化钠溶液对前列环素和内皮素的影响

比较３０例硬膜外阻滞择期手大患者，输入７．５％ＨＳ和５％ＧＳ后血浆ＰＧＩ２、ＥＴ及血流动力学的变化。输入ＨＳ后ＰＧＩ２明显升高，ＥＴ显著降低，伴主动脉顺应性快速增加。输入ＧＳ后１０分钟ＰＧＩ２和ＥＴ均无明显变化，６０分钟时ＰＧＩ２轻度增加，ＥＴ亦有上升，但较离散；ＴＰＲ持续增加，ＣＯ和ＳＶ短暂降低，血压明显下降。本研究提示ＰＧＩ２和ＥＴ在ＨＳ降低外周血管阻力、改善血流动力学过程中可能起着重要的介导作用。

Effects of hypertonic saline solution on prostacyclin and endotbelin.

The effects of hypertonic saline solution (HS) on prostacyclin (PGI2) and endothelin (ET) were evaluated.30 patients under epidural anesthesia during elective operations were infused with 7.5% HS (n=20) or 5% dextrose (n=10) 4ml/kg before anesthesia.PGI2, ET and hemodynamic indices were measured before and 10, 60 min after infusion.In HS group, the PGI2 increased about 51.4%, ET decreased 49.6% and the aortic compliance increased 37.5%. However.after dextrose infusion, PGI2 increased about 23.7% at 60 min, ET increased but dispersedly, with increased TPR and decreased CO, SV.Systolic pressure were declined over 20% in four out of ten patients.It demonstrated that HS could stimulate the secretion of PGI2 and depress ET. These hormonal changes revealed an important role in the course of decreasing TPR, with improving hemodynamios.