| 阿片受体在自发性高血压大鼠和正常大鼠中的不同分布(英文) |
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| 引用本文： | 殷霞,朱燕华,黄登凯,许绍芬. 阿片受体在自发性高血压大鼠和正常大鼠中的不同分布(英文)[J]. Acta pharmacologica Sinica, 1995, 0(4) |
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| 作者姓名： | 殷霞 朱燕华 黄登凯 许绍芬 |
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| 作者单位： | 上海医科大学神经生物学教研室，国家重点实验室，上海医科大学神经生物学教研室，国家重点实验室，上海医科大学神经生物学教研室，国家重点实验室，上海医科大学神经生物学教研室，国家重点实验室 上海 200032 中国，上海 200032 中国，上海 200032 中国，上海 200032 中国 |
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| 基金项目： | Project supported by the National Natural Science Foundation of China, №39370235，by the Science Foundation from the Ministry of Public Health, №0758112. |
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| 摘 要： | 目的:比较16周自发性高血压大鼠(SHR)和对照组Wistar-Kyoto(WKY)大鼠中枢神经系统中与血压调节有关的核团内阿片受体密度的变化.方法:用放射自显影方法,运用氚标依托啡作配基检测阿片受体的分布. 结果:在海马(P<0.01)、中央灰质、孤束核、胸髓(P<0.05)几处,SHR阿片受体密度较WKY大鼠低;而在杏仁核(P<0.01)、僵核(P<0.05)和下丘脑核群包括弓状核(P<0.01),SHR却有较高的阿片受体密度. 结论:不同分布的阿片受体与自发性高血压大鼠的血压有关.
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| 关 键 词： | 依托啡 阿片受体 高血压 脑 脊髓 放射自显影 近交SHR大鼠 近交WKY大鼠 |
Different distributions of opioid receptors in spontaneously hypertensive rats and Wistar-Kyoto rats |
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| YIN Xia,ZHU Yan-Hua,HUANG Deng-Kai,XU Shao-Fen. Different distributions of opioid receptors in spontaneously hypertensive rats and Wistar-Kyoto rats[J]. Acta pharmacologica Sinica, 1995, 0(4) |
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| Authors: | YIN Xia ZHU Yan-Hua HUANG Deng-Kai XU Shao-Fen |
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| Abstract: | To compare the densities of opioid receptors in spontaneously hypertensive rats (SHR) with those of normotensive Wistar-Kyoto (WKY) rats in central nervous system which are related to the regulation of BP. METHODS : [3 H ] Etorphine , a nonspecific opioid ligand, was used to determine the distributions of opioid receptors in 16-wk-old SHR and WKY rats by quantitative autora-diography . RESULTS : The densities of [3H] etorphine in hippocampus (P<0. 01), periaqueductal gray, nucleus of the solitary tract, and thoracic (T4 - 6) spinal cord (P<0. 05) of SHR were lower than those of WKY rats. But in basolateral amygdaloid nucleus (P
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| Keywords: | etorphine opioid receptors hypertension brain spinal cord autoradiography inbred SHR rats inbred WKY rats |
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