耳穴透穴埋针刺法治疗偏头痛的临床疗效及对血浆5-羟色胺含量的影响

目的:观察耳穴透穴埋针刺法治疗偏头痛的临床疗效及探讨其作用机制。方法:92例偏头痛患者按照就诊的先后顺序随机分为试验组和对照组,每组46例。试验组采用耳穴透穴埋针刺法,以额、颞、枕为主穴,伴有恶心、呕吐者加胃、交感,伴畏光者加眼,每次留针5 d,共埋针4次;对照组口服尼莫地平,40 mg/次,3次/d,连服4周。治疗结束后1个月和6个月分别评定两组近期疗效和远期疗效;采用荧光分光法检测两组治疗前后的血浆5-羟色胺(5-HT)含量。结果:治疗结束后1个月和6个月两组综合评分均低于治疗前(P0.01);组间综合评分比较,试验组均低于对照组(P0.01)。两组患者近期疗效比较,试验组总有效率82.61%(38/46),对照组总有效率67.39%(31/46),差异有统计学意义(P0.05);两组患者远期疗效比较,试验组总有效率83.72%(36/43),对照组总有效率57.14%(24/42),差异有统计学意义(P0.05)。治疗结束后两组血浆5-HT含量比较,试验组高于对照组(P0.05)。结论:耳穴透穴埋针刺法是治疗偏头痛的一种有效方法,其作用机制可能与提高患者血浆5-HT含量有关。

Effect of otopoint-needle embedment on headache and plasma 5-HT content in migraine patients

Objective To observe the effect of otopoint-needle embedment on migraine and to explore its underlying mechanism.Methods Ninety-two migraine outpatients were equally randomized into acupuncture group and medication group.For patients of the acupuncture group,one sterilized intradermal needle was inserted into E(MA-AT)-point and advanced toward Nie(Temple-point,MA-AT),then another inserted into Nie(Temple-point,MA-AT) and advanced toward Zhen(Occipus-point,MA-AT),followed by fixing the needles with a piece o...