Luminal A型乳腺癌的激素受体表达与绝经的相关性

目的探讨Luminal A型乳腺癌的激素受体表达水平与绝经的相关性，进一步认识该类乳腺癌的生物学特性。方法回顾性分析江苏省肿瘤医院2009年1月至2012年10月收治的135例LuminalA型乳腺癌患者的雌激素受体（estrogenreceptor，ER）及孕激素受体（progesteronereceptor，PR）的表达水平（高表达（H）〉50％；低表达（L）≤50％），比较ER、PR的不同表达分组在绝经前后患者中的差异及ER、PR间的相关性。结果绝经前LuminalA型乳腺癌ER—H／PR-H表达最常见（63．8％）；ERH／PR—L表达在绝经后患者中最常见（51．1％），在绝经前少见（17．0％）。ER、PR的相关性在绝经前比绝经后更明显（P值：0．003VS．0．047）。结论绝经前后的LuminalA型乳腺癌患者存在ER、PR的不同表达的差异性分布，体内雌激素水平可能是引起差异的原因。

Correlation between the expression of hormone receptor and the menopausal state in Luminal A breast carcinoma patients

Objective To explore the correlation between the expressions of hormone receptor and the menopausal state in Luminal A breast cancer patients, which help to realize the biological characteristics. Methods The expressions of ER, PR and the menopausal state of Luminal A breast cancers in Jiangsu Cancer Hospital between January 2009 and October 2012 were analyzed retrospectively. When breast caneers were elassifted based on ER and PR levels, the distribution of pre- and post-menapausals were compared and the relationship between ER and PR was analyzed. Results For Luminal A breast cancer, ER-H/PR-H cancers were frequent among pre-menapausals （63. 8% ）, ER-H/PR-L cancers were frequent among post-menapausals （51.1% ） , but rare among pre-menapausals（ 17.0% ）. Correlation between ER and PR levels among Luminal A cancers in pre-menapausals was stronger than that in post-menapausals（P： 0. 003 vs. 0. 047）. Conclusions The distribution of pre- and post-menapausals based on ER and PR levels is different among Luminal A breast cancer, which may be caused by the estrogen environment.