GM-CSF and G-CSF in Felty's syndrome

Summary The risk of infection is increased in patients with Felty's syndrome, neutropenia being one of the main reasons for the susceptibility to infection. We report the case of a 56-year-old patient with Felty's syndrome in whom successive therapy with GM-CSF, splenectomy, and G-CSF was tried because of recurrent severe infections. Therapy with GM-CSF and G-CSF resulted in improvement of neutropenia and in successful treatment of cutaneous and pulmonary infections.Abbreviations GM-CSF granulocyte-macrophage colonystimulating factor - G-CSF granulocyte colony-stimulating factorDedicated to Prof. Dr. N. Zöllner on the occasion of his 70th birthday