MUC1和MUC7蛋白在膀胱尿路上皮癌中的表达及临床意义

目的 探讨MUC1(Mucins 1)和MUC7(Mucins7)蛋白在膀胱尿路上皮癌中的表达及其与临床病理的相关性.方法 应用免疫组化技术检测50例膀胱尿路上皮癌和6例正常膀胱黏膜MUC1和MUC7蛋白的表达.结果 MUC1在正常膀胱黏膜及膀胱尿路上皮癌中都有不同程度的表达,50例膀胱尿路上皮癌标本中阳性表达是42例(84.0%),阳性表达率与肿瘤的病理分级、TNM分期显著相关.MUC7在正常膀胱黏膜无表达,50例膀胱尿路上皮癌中阳性表达37例(74.0%),MUC7的表达与临床分期有关,且有显著性差异,在浸润性膀胱癌中的表达高于表浅性膀胱癌,与肿瘤的病理分级无明显相关.结论 膀胱尿路上皮癌组织中MUC1和MUC7联合检测可作为判断膀胱尿路上皮癌分级,分期的一项参考指标.

Expression and Clinical Significance of MUC1 and MUC7 in Urine Epithelium of Bladder Tumor

Objectives To investigate the expression of MUC1 and MUC7 proteins and their significance in human urine epithelium of bladder tumor. Methods Immunohistochemistry was used to detect the expression of MUC1 and MUC7 proteins in 50 cases of urine epithelium of bladder tumor and 6 cases of normal bladder mucosa.Results MUC1 has different level of expression in both normal bladder mucosa and urine epithelium of bladder tumor. The positive expression of MUC1 in urine epithelium of bladder tumor was 42 cases( 84.0% ).Positive rate and expression patterns were correlated with high pathological grades and TNM stages. MUC7 was negative in all normal bladder mucos. The positive expression in urine epithelium of bladder tumor was 37 cases(74.0%). There was no significant different expreion of MUC7 with the pathological grades,but in different of clinical TNM stages. Conclusions There is a relationship between the expression of MUC1 and MUC7 in urine epithelium of bladder tumor, combining detection could be useful indicator for the assessment of pathological grades or TNM stages of urine epithelium of bladder tumor.