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| 糖化清蛋白酶法快速检测及其临床意义评价 | |
| 引用本文： | 吴杰红,张志伦,周良琼,刘萍,蒲晓允. 糖化清蛋白酶法快速检测及其临床意义评价[J]. 国际检验医学杂志, 2011, 32(17): 1920-1922. DOI: 10.3969/j.issn.1673-4130.2011.17.003 |
| 作者姓名： | 吴杰红 张志伦 周良琼 刘萍 蒲晓允 |
| 作者单位： | 第三军医大学新桥医院检验科,重庆,400037 |
| 摘 要： | 目的评价糖化清蛋白(GA)的酶法快速检测及其临床应用的意义。方法检测147例2型糖尿病(T2DM)患者及78例健康者的空腹血糖(FPG)、餐后2h血糖(2hBG)、糖化血红蛋白(HbAlc)等指标;同时应用液态酶法测定GA,用GA高值血清和低值血清评估试剂盒的精密度及其线性,建立GA参考范围;分析GA与各检测指标的相关性。结果健康人群GA值为(14.48±2.12)%;对147例患者的相关性分析显示,GA与HbA1c具有良好的相关性(r=0.868 7,P<0.01);GA与FPG、2hBG呈正相关(r=0.854、0.836,P<0.01);HbA1c>7.0%、4.0%≤HbA1c≤7.0%以及HbA1c<4.0%患者GA与HbA1c的相关系数分别为0.823(P<0.01)、0.756(P<0.05)和0.187(P>0.05);健康者、临界者和T2DM患者间GA差异有统计学意义(P<0.001)。结论该法批内变异系数(CV)<2%,批间CV<5%,线性测定r=0.998 7。GA与HbA1c具有良好的相关性,尤其表现于长期血糖控制欠佳的患者。酶法检测GA有良好的精密度和线性。 |
| 关 键 词： | 糖尿病,2型 血红蛋白A,糖基化 糖化血清白蛋白 |
Primary assessment of enzymatic measurement of glycated albumin |
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| Wu Jiehong,Zhang Zhilun,Zhou Liangqiong,Liu Ping,Pu Xiaoyun. Primary assessment of enzymatic measurement of glycated albumin[J]. International Journal of Laboratory Medicine, 2011, 32(17): 1920-1922. DOI: 10.3969/j.issn.1673-4130.2011.17.003 | |
| Authors: | Wu Jiehong Zhang Zhilun Zhou Liangqiong Liu Ping Pu Xiaoyun |
| Affiliation: | △(Department of Laboratory Medicine,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China) |
| Abstract: | Objective To evaluate the clinical significance of fast enzymatic measurement of glycated albumin(GA).Methods 143 cases of patients with type 2 diabetes mellitus(DM) and 78 cases of healthy controls were enrolled,for whom the fasting plasma glucose(FPG),postprandial 2 hours blood glucose(2hBG) and glycated hemoglobin(HbA1c) were measured.At the same time,the levels of GA were detected by using enzymatic measurement,the precision and linear rage of the detection kits were analyzed by the detection of samples... |
| Keywords: | diabetes mellitus Type 2 hemoglobinA glycosylated glycated albumin |
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