| Th17细胞的分化调控与自身免疫性疾病 |
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| 引用本文： | 郭静雅,邱玉华. Th17细胞的分化调控与自身免疫性疾病[J]. 国际免疫学杂志, 2010, 33(4): 249-252. DOI: 10.3760/cma.j.issn.1673-4394.2010.04.001 |
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| 作者姓名： | 郭静雅 邱玉华 |
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| 作者单位： | 苏州大学医学部免疫学系,215123;苏州大学医学部免疫学系,215123 |
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| 基金项目： | 科技部重大专项资助项目 |
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| 摘 要： | Th17细胞是最近发现的一种在分化和功能上均不同于Th1和Th2的新型CD4＋T细胞亚群.该群细胞以主要分泌细胞因子IL-17而得名.IL-6、TGF-β、IL-21及IL-23等对Th17细胞的分化调控发挥重要作用.研究表明,Th17细胞可参与多种自身免疫性疾病的发生、发展与转归.
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| 关 键 词： | Th17细胞 IL-17 自身免疫性疾病 |
The differentiation and regulation of Th17 cell and autoimmune diseases |
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| GUO Jing-ya,QIU Yu-hua. The differentiation and regulation of Th17 cell and autoimmune diseases[J]. International Journal of Immunology, 2010, 33(4): 249-252. DOI: 10.3760/cma.j.issn.1673-4394.2010.04.001 |
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| Authors: | GUO Jing-ya QIU Yu-hua |
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| Affiliation: | .(Immunology of Medical Department of Soochow University, Suzhou 215123, China) |
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| Abstract: | The latest revealed Th17 cell belongs to a new subgroup of CD4+T cell which differs from Th1 and Th2 on differentiation and function.The cell is so named because of its characteristic of mainly excreting cytokine IL-17.Cytokine IL-6,TGF-β,IL-21 and IL-23 all of them play important roles in differentiation and regulation of Th17 cell.Studies showed that Th17 cell can participate in the development of mutiple autoimmne diseases. |
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| Keywords: | IL-17 |
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