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| 神经节甙抗体在儿童系统性红斑狼疮脑病诊断中的意义 | |
| 引用本文： | 陈燕 何晓琥. 神经节甙抗体在儿童系统性红斑狼疮脑病诊断中的意义[J]. 中华儿科杂志, 1996, 34(6): 404-406 |
| 作者姓名： | 陈燕 何晓琥 |
| 作者单位： | 北京市儿科研究所，首都医科大学附属北京儿童医院 |
| 摘 要： | 为了解儿童系统性红斑狼疮（ＳＬＥ）及狼疮脑病（ＮＰＬＥ）时抗神经节甙抗体（ＡＧＡ）的存在及血清或脑脊液中ＡＧＡ的临床相关性。采用酶标记免疫测定法检测了４７例ＳＬＥ患儿（其中１３例临床诊断为ＮＰＬＥ）的７１份血清标本、８份脑脊液标本中的ＡＧＡ水平。结果脑脊液中的ＡＧＡ与ＮＰＬＥ有明显相关性，５例ＮＰＬＥ脑脊液中ＩｇＧ－ＡＧＡ阳性、４例ＩｇＭ－ＡＧＡ阳性。２例的纵向观察显示脑脊液中的ＡＧＡ变化与临床病程相关。提示ＡＧＡ有可能作为儿童ＮＰＬＥ诊断的重要指标之一。 |
| 关 键 词： | 红斑狼疮.系统性 神经节甙抗体 脑疾病 |
Antigangliosideantibodiesinchildrenwithneuropsychiatriclupuserythematosus |
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| ChenYan,HeXiaohu,HouLiyan,et al.. Antigangliosideantibodiesinchildrenwithneuropsychiatriclupuserythematosus[J]. Chinese journal of pediatrics, 1996, 34(6): 404-406 | |
| Authors: | ChenYan HeXiaohu HouLiyan et al. |
| Affiliation: | ChenYan,HeXiaohu,HouLiyan,etal.BeijingPediatricResearchInstitute,Beijing100045 |
| Abstract: | Todeterminethepresenceofantigangliosideantibodies(AGA)inchildrenwithneu-ropsychiatriclupuserythematosus(NPLE)anditsassociationwithclinicalcourse,weexamined71serumsamplesand8CSFsamplesfrom47childrenwithsystemiclupuserythematosus(SLE),a-mongwhom13caseswereclinicalydiagnosedasNPLE.SignificantcorrelationwasfoundbetweenAGAincerebrospinalfluid(CSF)andNPLE.CSFspecimensofalthe5patientswithNPLEwerepositiveforIgG-AGAand4ofthemhadpositiveIgM-AGA.Alongitudinalstudyof2casesshowedthatAGAvariedwithclinicalcourses.NosignificantdiferencesinserumAGAwereseenbetweenpatientswithNPLEandthosewithoutNPLE.ThepresentstudysuggeststhatAGAmaybeoneofthemarkersforthediagnosisofNPLEinchildren.Thisresultalsosupportsthehypothesisthatin-trathecalantibodyproductionplaysanimportantroleinimmunopathologicprocessofNPLE. |
| Keywords: | Lupuserythematosus systemicAntigangliosideantibodiesBraindiseases |
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