米非司酮用于足月妊娠引产的价值探讨

目的：探讨米非司酮用于足月妊娠引产的临床效果、药物副反应以及药物对胎儿的安全性。方法：将66例有引产指征的孕足月单胎头位的初产妇，随机分为两组，研究组（33例）用米非司酮50mg口服，每12小时一次，共4次；对照组（33例）静脉点滴催产素引产。结果：研究组用48小时后宫颈评分增加与对照组差异显著（P＜0．01），研究组引产总有效率高于对照（P＜0．05），用药后临产发动时间显著短于对照组（P＜0．01）；而两组剖宫产率、产后出血率、胎儿窘迫及新生儿窒息率、药物副反应率均无显著差异（P＞0．05）。结论：米非司酮具有良好的促宫颈成熟作用，可配伍米索前列醇或催产素用于足月妊娠引产。

Mifepristone for Induction of Labour in Term Pregnancy

To evaluate the effectiveness of Mifepristone as an inductive agent in term pregnancy, and study the side effects and safety of such treatment for both the mother and the fetus.Method: 66 nullipara with indication for induction of labour were randomly assigned to twogroups: the mifepristone group (33 cases) received mifepristone 50mg orally every 12 hours for atotal of 200mg. The control group (33 cases) received oxytocin. Results: The mean Bishopscores taken 48 hours after drug administration increased significantly in the mifepristone groupover the control group (P < 0. 01 ). The overall effectiveness of the induction of labour was alsosignificantly higher in the mifepristone group than in the control group (P < 0.05). The induction and total labour time was noticeably shorter with the mifepristone group (P < 0. 01).There was no significant difference between the two groups in the occurrences of caesarean sections, postpartum hemorrhage, fetus distress, neonatal asphyxia, or pharmaceutical side effects(P > 0. 05). Conclusion: Mifepristone can effectively induce cervical ripening and can be used inassociation with misoprostol or oxytocin for the induction of labour in term pregnancy.