154例慢性自发性 荨麻疹患者自体血清皮肤试验结果分析

目的探讨慢性自发性荨麻疹患者自体血清皮肤试验在临床中的应用价值。方法对154例慢性自发性荨麻疹患者及30名健康志愿者做自体血清皮肤试验,并对结果进行分析。结果 154例患者中67例(43.5%)患者检出阳性结果,对照组全部阴性;自体血清皮肤试验阳性与阴性的慢性自发性荨麻疹患者在性别、年龄分布及病程上差异无统计学意义(P0.05),自体血清皮肤试验阳性的慢性自发性荨麻疹患者症状评分及瘙痒持续时间明显高于阴性患者(P0.05),自体血清皮肤试验阳性程度与瘙痒持续时间呈正相关(P0.05)。自体血清皮肤试验阳性的慢性自发性荨麻疹患者伴发过敏史(药物、食物、吸入物)的比例高于阴性的患者(P0.05)。结论自体血清皮肤试验阳性的慢性自发性荨麻疹患者较阴性者病情重,该试验作为慢性荨麻疹功能性自身抗体的筛选试验可在临床上广泛应用。

Analysis of Autologous Serum Skin Test Results in 154 Cases of Patients with Chronic Spontaneous Urticaria

Objective In order to investigate the clinic value of autologous serum skin test (ASST) in chronic spontaneous urticarial (CSU).Methods Autologous serum skin test was used in 154 patients with CSU and 30 healthy controls.Results Among 154 patients,67 patients (43.5％) were detected positive results,while all healthy control were detected negative results (P＜0.05).There was no significant difference on gender,age distribution and course,between the patients ASST positive and ASST negative (P＞O.05).The symptom score in the patients ASST positive was significantly higher than that of the patients ASST negative (P＜0.05),and the itching duration was significantly longer than that of the patients ASST negative (P＜0.05).There was a positive correlation between the itching duration and the positive degree in ASST.The rate associated with allergic history in the patients ASST positive was significantly higher than that of the patients ASST negative (P＜0.05).Conclusion The clinical symptoms of the patients ASST positive were more severe than those of the patients ASST negative.As a screening test of the functional autoantibody in chronic urticaria,ASST could be wildly used in clinic.