| MicroRNA在人类肿瘤中的角色及其应用 |
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| 引用本文： | 柯慧,丁彦青,王爽. MicroRNA在人类肿瘤中的角色及其应用[J]. 国际病理科学与临床杂志, 2009, 29(3): 225-230 |
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| 作者姓名： | 柯慧 丁彦青 王爽 |
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| 作者单位： | 南方医科大学病理教研室,广州,510515;南方医科大学病理教研室,广州,510515;南方医科大学病理教研室,广州,510515 |
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| 摘 要： | 微小RNA（microRNAs,miRNAs）是一类含有约22个核苷酸的内源性非编码RNAs,通过与靶基因mRNA的3′端非翻译区（3′untranslated region,3′UTR）不完全性互补配对,介导转录后基因调控。miRNAs在人类肿瘤的发生和发展中扮演重要角色,发挥着癌基因或抑癌基因的作用。miRNAs可以作为肿瘤的生物标记和诊断工具,将成为新一代的抗肿瘤治疗的靶点。
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| 关 键 词： | microRNA 肿瘤 诊断 治疗 |
| 收稿时间： | 2009-01-20 |
| 修稿时间： | 2009-06-09 |
Role of microRNAs in human tumor and its applications |
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| KE Hui,DING Yanqing,WANG Shuang. Role of microRNAs in human tumor and its applications[J]. Journal of International Pathology and Clinical Medicine, 2009, 29(3): 225-230 |
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| Authors: | KE Hui DING Yanqing WANG Shuang |
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| Affiliation: | Department of Pathology, Southern Medical University,Guangzhou 510515, China |
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| Abstract: | MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, which mediate the post-transcriptional gene modulation by annealing to incomplete complementary sequences in the 3′ untranslated regions of target mRNAs. MicroRNAs play important roles in the occurrence and development of human tumor, and act as either tumor suppressors or oncogenes. They can be used as diagnostic markers of tumor and will become the new anti-cancer therapeutic targets in the future. |
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| Keywords: | microRNA |
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