复方氨基酸胶囊对舰艇官兵免疫功能的影响

目的 探讨复方氨基酸胶囊对舰艇官兵免疫功能的影响.方法 将100名改良疲劳评定量表(MFIS)评分＞21分的舰艇官兵随机分为胶囊组和安慰剂组(n=50),分别给予复方氨基酸胶囊和安慰剂胶囊,在参加军事作业的情况下,连续服用14d.分别在服用的第1天和第14天采用免疫比浊法检测体液免疫指标IgG、IgM、IgA及补体C3、C4,采用流式细胞仪检测外周血T淋巴细胞亚群水平.结果 服用第14天,胶囊组舰艇官兵IgG、IgGM及补体因子C3与第1天比较显著增高(P＜0.05),在对照组则无显著性差异;胶囊组舰艇官兵CD3+CD4+T淋巴细胞、CD3-CD19+B淋巴细胞与第1天比较均显著升高,CD3-CD56+ NK淋巴细胞与第1天比较显著降低(P＜0.05),而对照组则无显著性差异.结论 复方氨基酸胶囊能提高舰艇官兵的体液和细胞免疫功能.

Effects of compound amino acids capsule on the immunological function of naval servicemen

Objective The present study was to investigate the effects of the compound amino acids capsule on the immunological function of the naval servicemen during military activity.Methods The subjects included 100 officers and soldiers,whose Modified Fatigue Rating Scale(MFIS) scores were >21 points.The participants were randomly divided into two groups,namely,the amino acids capsule group and placebo group(n=50).Under the condition of military operations,either amino acid or placebo capsules was given for 14 days continuously.The humoral immune indices,i.e.,IgG,IgA,IgM,and complements C3 and C4,were measured with immunoturbidimetry.The percentage of peripheral blood CD subsets was measured using flow cytometry on the first day and 14th day.Results The levels of IgG,IgM,and complement C3 of the capsule group were significantly higher in 14th day than that on the first day(P<0.05),and no significant difference of their levels was observed in the control group.The CD3+CD4+T lymphocytes and CD3-CD19+ B lymphocytes in the capsule group on the 14th day were higher than that on the first day,whereas the CD3-CD56+ NK lymphocytes decreased significantly(P<0.05).There was no significant difference in the control group.Conclusion Compound amino acids capsule can improve the humoral and cellular immunological function of naval servicemen.