| 非甾体抗炎药药物代谢酶多态性的研究进展 |
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| 引用本文： | 胡成穆,李俊,徐叔云.非甾体抗炎药药物代谢酶多态性的研究进展[J].安徽医药,2002,6(2):3-6. |
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| 作者姓名： | 胡成穆 李俊 徐叔云 |
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| 作者单位： | 安徽医科大学临床药理研究所、药学系,合肥,230032 |
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| 摘 要： | 非甾体抗炎药(NAIDs)是一类具有解热、镇痛和抗炎作用的药物,临床上用于治疗骨关节炎、类风湿关节炎等疾病,疗效确切但常伴有胃肠道不适等不良反应,其产生与其药物代谢酶的遗传多态性有关.参与NSAIDs氧化代谢的细胞色素P450酶系,主要有CYP2C9、CYP1A2、CYP2E1和CYP3A4,本文就NSAIDs的药物代谢酶及其多态性和P450代谢的部分NSAIDs(双氯芬酸、布洛芬、氟比洛芬、萘普生和醋氨芬)等作一综述.
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| 关 键 词： | 非甾体抗炎药 药物代谢 细胞色素氧化酶P450 遗传多态性 |
Progress in polymorphic drug-metabolizing enzymes of NSAIDs |
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| HU Cheng Mu,LI Jun,XU Shu Yun.Progress in polymorphic drug-metabolizing enzymes of NSAIDs[J].Anhui Medical and Pharmaceutical Journal,2002,6(2):3-6. |
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| Authors: | HU Cheng Mu LI Jun XU Shu Yun |
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| Abstract: | Non steroidal anti inflammatory durgs(NSAIDs) havethe antipyretic, analgesic and anti inflammatory effects which widely used to treat patients with rheumatoid arthritis(RA) and osteoarthritis. They could cause some seriously adverse reactions though have special therapeutic effects. NSAIDs adverse reactions are associated with genetic polymorphisms of their drug metabolizing enzymes. The cytochrome P450 isoforms such as CYP2C9, CYP1A2, CYP2E1 and CYP3A4 are involved in the metabolism of NSAIDs. CYP450s responsible for NSAIDs and their genetic polymorphisms are described in this paper and several NSAIDs (diclofenac, ibuprofen, flurbiprofen, naproxen and acetaminophen) metabolized by CYP450s are reviewed. |
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| Keywords: | NSAIDs drug metabolism cytochrome P450 genetic polymorphism |
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