| 双氧水降解卡拉胶选择清除低密度脂蛋白性能的研究 |
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| 引用本文： | 上官阿路,刘玮,方波. 双氧水降解卡拉胶选择清除低密度脂蛋白性能的研究[J]. 中国血液流变学杂志, 2011, 21(1): 17-20. DOI: 10.3969/j.issn.1009-881X.2011.01.006 |
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| 作者姓名： | 上官阿路 刘玮 方波 |
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| 作者单位： | 华东理工大学化学工程研究所,上海,200237 |
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| 摘 要： | 该文以卡拉胶为原料,采用双氧水降解,制备出一种低密度脂蛋白净化剂.考察了净化剂浓度、净化体系pH值对血浆低密度脂蛋白胆固醇(LDL-C)净化效果的影响,得到较优化的诱导沉淀条件.体外间歇诱导沉淀实验表明,该净化剂对血浆总胆固醇(TC)的平均净化率为66.1%,对LDL-C平均净化率为83.7%,对高密度脂蛋白胆固醇(H...
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| 关 键 词： | 卡拉胶 降解 低密度脂蛋白净化 |
Research on Selective Removal of Low Density Lipoprotein by Degraded Carrageenan with Hydrogen Peroxide |
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| SHANGGUAN A-lu,LIU Wei,FANG Bo. Research on Selective Removal of Low Density Lipoprotein by Degraded Carrageenan with Hydrogen Peroxide[J]. Chinese Journal of Hemorheology, 2011, 21(1): 17-20. DOI: 10.3969/j.issn.1009-881X.2011.01.006 |
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| Authors: | SHANGGUAN A-lu LIU Wei FANG Bo |
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| Affiliation: | (Chemical Engineering Research Center, East China University of Science and Technology, Shanghai 200237,China) |
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| Abstract: | An agent for Low-density Lipoprotein-apheresis was prepared by degradation of carrageenan with hydrogen peroxide.The effects of the purifying agent concentration and pH value on the selective precipitation of low density lipoprotein cholesterol（LDL-C） was investigated,the optimal conditions for LDL-precipitation were obtained.The results of precipitation in vitro showed that the average purifying percentage for LDL-C,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C） and total protein（TP） was 83.7%,66.1%,24.3% and 13.5% respectively.The purifying agent possesses good selectivity in removal of LDL-C. |
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| Keywords: | Carrageenan degradation Low-density lipoprotein-apheresis |
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