超敏C反应蛋白、血清载脂蛋白与冠心病的关系

目的 观察冠心病患者血清载脂蛋白B（ApoB）、超敏C反应蛋白（hs-CRP）的变化及临床意义.方法 测定50例不同类型的冠心病患者的ApoB和hs-CRP水平,并且与42名健康者比较.结果 与健康对照组相比,冠心病组的血ApoB和hs-CRP水平明显增高（P＜0.05）.随着病变程度的加重,ApoB、hs-CRP水平明显升高,hs-CRP浓度与病变积分呈正相关（r＝0.832）,ApoB浓度与病变积分呈正相关（r＝0.697） P＜0.05）.结论 ApoB和hs-CRP同冠心病关系密切,是冠心病的危险因素.

Relationship of high sensitivity C-reactive protein, serum ApoB and coronary heart disease

Objective To study the changes and their clinical significance of serum ApoB and high sensitivity protein （hs-CRP） in patients with Coronary heart disease. Methods ApoB and hs-CRP in 50 patients with various CHD were measured and compared with those in 46 healthy controls. Results The levels of hs- CRP, ApoB were significantly higher in CHD group than those in healthy group（P〈0.05 ）. As grade of lesion wors- en, the levels of hs-CRP, ApoB were significantly increasing. Hs-CRP （r=0.832） and ApoB （r=0.697） were positively correlative with coronary artery lesions（P〈0.05）. Conclusion ApoB and hs-CRP associated with CHD. They are risk factors for CHD.